Protein Alignment Ance-5 and ACE

DIOPT Version :10

• Sequence 1: NP_573392.2
• Gene: Ance-5 / 37980
• FlyBaseID: FBgn0035076
• Length: 628
• Species: Drosophila melanogaster
• Sequence 2: NP_000780.1
• Gene: ACE / 1636
• HGNCID: 2707
• Length: 1306
• Species: Homo sapiens
• Alignment Length: 595
• Identity: 162/595 - (27%)
• Similarity: 284/595 - (47%)
• Gaps: 64/595 - (10%)

  Fly    44 WSLNRRIFVQLTAKGKSPLGGQVLNSKLEVEAETYRLFYDLAGNLSVVSVAELNDPLLRRRVQRM 108
            |:.|..|..: |:|.......|:.|..|:...:..:.           .|.:|.:..::|.::::
Human   672 WNYNTNITTE-TSKILLQKNMQIANHTLKYGTQARKF-----------DVNQLQNTTIKRIIKKV 724

  Fly   109 AKLQLQGLRPKDYEQAKDLLRQIHNFVNGPLVC-PYEDCSARGSLAMYPQIMNKNMHTKLYEDLV 172
            ..|:...|..::.|:...:|..:....:...|| |...|     |.:.|.:.|....::.||||:
Human   725 QDLERAALPAQELEEYNKILLDMETTYSVATVCHPNGSC-----LQLEPDLTNVMATSRKYEDLL 784

  Fly   173 INWKAWR----RAINEKDVAKNTFIGYVRLLRIAATYNGHVTPSRTWYLNYDTENFQAEMEAVVW 233
            ..|:.||    |||.:      .:..||.|:..||..||:|....:|...|:|.:.:.::|.:..
Human   785 WAWEGWRDKAGRAILQ------FYPKYVELINQAARLNGYVDAGDSWRSMYETPSLEQDLERLFQ 843

  Fly   234 EIMPLYRELHAYLRREVQAAYPKADTKSDGAISAPIMDQILSQDW---------YPHQFFRTPHQ 289
            |:.|||..||||:||.:...|.......:|.|.|.::..:.:|.|         :|
Human   844 ELQPLYLNLHAYVRRALHRHYGAQHINLEGPIPAHLLGNMWAQTWSNIYDLVVPFP--------- 899

  Fly   290 GRQHQLPSVHRRLEEVLV---TPVKINRKAAEFFESLGLMVMPNIFYDR--FSRRMNDEEGGAEC 349
                ..||:. ..|.:|.   ||.::.::|.:||.||||:.:|..|:::  ..:..:..|.....
Human   900 ----SAPSMD-TTEAMLKQGWTPRRMFKEADDFFTSLGLLPVPPEFWNKSMLEKPTDGREVVCHA 959

  Fly   350 KSQVYYFPPDVALRYCPKLDYKKMMQIHGTMAELQYHLYKMQLPFGLDTEPCPGFGAAIAETVIL 414
            .:..:|...|..::.|..::.:.::..|..|..:||.:....||..|.....|||..||.:.:.|
Human   960 SAWDFYNGKDFRIKQCTTVNLEDLVVAHHEMGHIQYFMQYKDLPVALREGANPGFHEAIGDVLAL 1024

  Fly   415 ASGTPRHLHRLHILLNDSLTEEQSLNRLFRMGVHTLIAVPQYFINDKFLVDVMDGRIGVKDYNCA 479
            :..||:|||.|::|.::..::|..:|.|.:|.:..:..:|..::.|::...|.||.|..::||..
Human  1025 SVSTPKHLHSLNLLSSEGGSDEHDINFLMKMALDKIAFIPFSYLVDQWRWRVFDGSITKENYNQE 1089

  Fly   480 YWGLQDKFAGVQPPLQRLNKDFDVDFKFYRGLNPETSNTKKFLAEILGFQFYRSFCLASGQYKPG 544
            :|.|:.|:.|:.||:.|...|||...||:  :.......:.|::.|:.|||:.:.|.|:|.
Human  1090 WWSLRLKYQGLCPPVPRTQGDFDPGAKFH--IPSSVPYIRYFVSFIIQFQFHEALCQAAGH---- 1148

  Fly   545 DPNFPLHNCDFYDSKEAGKKIRDMMQLGATRHWRDVMEIATGERKLSGRGILEYFAPLFTWLKER 609
              ..|||.||.|.|||||:::...|:||.:|.|.:.|::.||:..:|...:|.||.||..||:..
Human  1149 --TGPLHKCDIYQSKEAGQRLATAMKLGFSRPWPEAMQLITGQPNMSASAMLSYFKPLLDWLRTE 1211

  Fly   610 NKQLDIEPGW 619
            |:....:.||
Human  1212 NELHGEKLGW 1221

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ance-5	NP_573392.2	M2_ACE	67..610	CDD:341055	153/561 (27%)
ACE	NP_000780.1	Peptidase_M2	40..623	CDD:460196
		Peptidase_M2	643..1221	CDD:460196	160/593 (27%)
		Juxtamembrane stalk. /evidence=ECO:0000269|PubMed:11274151	1215..1256		2/7 (29%)