DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ance-5 and ace

DIOPT Version :9

Sequence 1:	NP_573392.2	Gene:	Ance-5 / 37980	FlyBaseID:	FBgn0035076	Length:	628	Species:	Drosophila melanogaster
Sequence 2:	NP_001116882.1	Gene:	ace / 100144634	XenbaseID:	XB-GENE-479789	Length:	1284	Species:	Xenopus tropicalis

Alignment Length:	602	Identity:	165/602 - (27%)
Similarity:	274/602 - (45%)	Gaps:	78/602 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    44 WSLNRRIFVQLTAKGKSPLGGQVLNSKLEVEAETYRLFYDL-AGNLSVVSVAELNDPLLRRRVQR 107
            |:.|..|    |...|..:    |:..|.:...|  |.|.| |.|   ...::..||..:|.:::
Frog   660 WAYNTNI----TEANKQVM----LDKNLAMSGHT--LQYGLQARN---YDYSDFQDPETQRILRK 711

  Fly   108 MAKLQLQGL---RPKDYEQAKDLLRQIHNFVNGPLVCPYEDCSARGSLAMYP------QIMNKNM 163
            ::::....|   ..|:|.|....:..|::...   ||  :|    |:...:|      :|:.|
Frog   712 LSEIDKAALSEEEQKEYNQITSDMETIYSVAK---VC--KD----GNTNCHPLDPDLTEILAK-- 765

  Fly   164 HTKLYEDLVINWKAWRRA----INEKDVAKNTFIGYVRLLRIAATYNGHVTPSRTWYLNYDTENF 224
             ::.|::|:..||.||.|    |.||      :..||:|...||..||:......|...|:|...
Frog   766 -SRDYDELLFAWKGWRDASGKQIREK------YKRYVQLANKAAQLNGYNDNGAYWRSWYETPTL 823

  Fly   225 QAEMEAVVWEIMPLYRELHAYLRREVQAAYPKADTKSDGAISAPIMDQILSQDW---------YP 280
            ::::|.:..|:.|||..||||:||.:...|........|.|.|.::..:.:|.|         ||
Frog   824 ESDVEKLYDELQPLYLNLHAYVRRALYKKYGDKRINLKGPIPAHLLGNMWAQSWSNIYELLVPYP 888

  Fly   281 H--QFFRTPHQGRQHQLPSVHRRLEEVLVTPVKINRKAAEFFESLGLMVMPNIFYDR-FSRRMND 342
            :  |...||....::.             ||.::..::..||:||||:.||..|:|: ...:..|
Frog   889 NAAQVDATPAMIAKNW-------------TPKRMFEESDNFFKSLGLLPMPQEFWDKSMIEKPKD 940

  Fly   343 EEGGAECKSQVYYFPPDVALRYCPKLDYKKMMQIHGTMAELQYHLYKMQLPFGLDTEPCPGFGAA 407
            .|......:..:|...|..::.|..::...::.:|..|..:||.|.....|........|||..|
Frog   941 REVVCHASAWDFYNRKDFRIKQCTVVNMDDLITVHHEMGHVQYFLQYKDQPILFREGANPGFHEA 1005

  Fly   408 IAETVILASGTPRHLHRLHILLNDSLTEEQSLNRLFRMGVHTLIAVPQYFINDKFLVDVMDGRIG 472
            |.:.:.|:..||:||..:.:|.......|..:|.|..:.:..:..:|..|:.|::...|.|||..
Frog  1006 IGDVLALSVSTPKHLQSIGLLDKVEDNPESDINYLMSIALDKIAFLPFGFLMDQWRWKVFDGRTP 1070

  Fly   473 VKDYNCAYWGLQDKFAGVQPPLQRLNKDFDVDFKFYRGLNPETSNTKKFLAEILGFQFYRSFCLA 537
            ..:||..:|.|:.|:.|:.||:.|...|||...||:  :.......:.|::.::.|||:.:.|.|
Frog  1071 DSEYNQQWWNLRLKYQGLVPPVLRTENDFDPGAKFH--IPASVPYIRYFISFVIQFQFHEALCKA 1133

  Fly   538 SGQYKPGDPNFPLHNCDFYDSKEAGKKIRDMMQLGATRHWRDVMEIATGERKLSGRGILEYFAPL 602
            :.|      ..|||.||.|.|.:|||.:.|.|:||.::.|.:.|:..||:|.:|...:|:||.||
Frog  1134 ANQ------EGPLHKCDIYQSTQAGKLLGDAMKLGNSKPWPEAMQTITGQRNMSAHALLKYFQPL 1192

  Fly   603 FTWLKERNKQLDIEPGW 619
            ..||.:.|.:.....||
Frog  1193 TDWLIKENTKNGETLGW 1209

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ance-5	NP_573392.2	GluZincin	93..610	CDD:301352	149/541 (28%)
ace	NP_001116882.1	Peptidase_M2	28..611	CDD:279709
ace	NP_001116882.1	Peptidase_M2	631..1209	CDD:279709	163/600 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D266227at33208
OrthoFinder	1	1.000	-	-		FOG0000442
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	3.010