DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment KIF5A and KIP2

DIOPT Version :9

Sequence 1:	NP_004975.2	Gene:	KIF5A / 3798	HGNCID:	6323	Length:	1032	Species:	Homo sapiens
Sequence 2:	NP_015170.1	Gene:	KIP2 / 855948	SGDID:	S000006076	Length:	706	Species:	Saccharomyces cerevisiae

Alignment Length:	723	Identity:	181/723 - (25%)
Similarity:	281/723 - (38%)	Gaps:	231/723 - (31%)

- Green bases have known domain annotations that are detailed below.

Human    32 PIFQGDDSVVIGGK--PYVFDRVFPPNTTQEQVYHACAMQIVKDVLAGYNGTIFAYGQTSSGKTH 94
            |.|..:|..::..:  .:.||.||..:.|..:||...:..::..:|.|:|.||||||.|.||||.
Yeast   146 PWFITNDKTIVHEEIGEFKFDHVFASHCTNLEVYERTSKPMIDKLLMGFNATIFAYGMTGSGKTF 210

Human    95 TMEGKLHDPQLMGIIPRIARDIFNHI--YSMDENLEFHIKVSYFEIYLDKIRDLLD--------- 148
            ||.|   :.|.:|:||.....:|.:|  .||:.:.:|.:.:||.|||.::|.|||:
Yeast   211 TMSG---NEQELGLIPLSVSYLFTNIMEQSMNGDKKFDVIISYLEIYNERIYDLLESGLEESGSR 272

Human   149 --------VTKTN-------LSVHEDKNRVPFVKGCTERFVSSPEEILDVIDEGKSNRHVAVTNM 198
                    ::|:|       |.:.:|......|.|.|||...|.||:|..|..|..:|.:..|:.
Yeast   273 ISTPSRLYMSKSNSNGLGVELKIRDDSQYGVKVIGLTERRCESSEELLRWIAVGDKSRKIGETDY 337

Human   199 NEHSSRSHSIFLINIKQENMETEQKLSGKLYLVDLAGSEKVSKTGAEGAVLDEAKNINKSLSALG 263
            |..|||||:|.||.:...|::.....|..|.|.||||||:.  ||.:.. ..|...|||||.|||
Yeast   338 NARSSRSHAIVLIRLTSTNVKNGTSRSSTLSLCDLAGSERA--TGQQER-RKEGSFINKSLLALG 399

Human   264 NVISAL----------------AEGTKS--------------YVPYRDSKMTRILQDSLGGNCRT 298
            .|||.|                |.|:.|              ::||||||:||:||.:|.|:...
Yeast   400 TVISKLSADKMNSVGSNIPSPSASGSSSSSGNATNNGTSPSNHIPYRDSKLTRLLQPALSGDSIV 464

Human   299 TMFICCSPSSYND--AETKSTLMFGQRAKTIKNTASVNLELTAEQWKKKYEKEKEKTKAQKETIA 361
            |..  |:..:.||  |||.:||.|..|||.:....|                        |::|.
Yeast   465 TTI--CTVDTRNDAAAETMNTLRFASRAKNVALHVS------------------------KKSII 503

Human   362 KLEAELSRWRNGENVPETERLAGEEAALGAELCEETPVNDNSSIVVRIAPEERQKYEEEIRRLYK 426
            .         ||.|..:.:|..                                   |.:||
Yeast   504 S---------NGNNDGDKDRTI-----------------------------------ELLRR--- 521

Human   427 QLDDKDDEINQQSQLIEKLKQQMLDQEELLVSTRGDNEKVQRELSHLQSENDAAKDEVKEVLQAL 491
                   ::.:|.::|.:||.:....|.|   |:..||...:::....::.|.     ...|...
Yeast   522 -------QLEEQRRMISELKNRSNIGEPL---TKSSNESTYKDIKATGNDGDP-----NLALMRA 571

Human   492 EELAVNYDQKSQEVEEKSQQNQLLVDELSQKVATMLSLESELQRLQEVSGHQRKRIAEVLNGLMK 556
            |...:.|         |.:..:.|:|                   ::|...|...|.|::.
Yeast   572 ENRVLKY---------KLENCEKLLD-------------------KDVVDLQDSEIMEIVE---- 604

Human   557 DLSEFSVIVGNGEIKLPVEISGAIEEEFTVARLYISKIKSEVKSVVKRCRQLEN----LQVECHR 617
                          .||.|:...:|.:|       ..::|:::...|..::||:    |:...|.
Yeast   605 --------------MLPFEVGTLLETKF-------QGLESQIRQYRKYTQKLEDKIMALEKSGHT 648

Human   618 KMEVT---GRELSSCQLLISQHEAKIRSLTEYMQSVELKKRHLEESYDSLSDELAK--LQAQETV 677
            .|.:|   |.|:...|.::.:.:..|.:|               :|...|.|...|  :..|::.
Yeast   649 AMSLTGCDGTEVIELQKMLERKDKMIEAL---------------QSAKRLRDRALKPLINTQQSP 698

Human   678 HEVALKDK 685
            |.|...||
Yeast   699 HPVVDNDK 706

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
KIF5A	NP_004975.2	KISc_KHC_KIF5	7..327	CDD:276820	124/354 (35%)
		Microtubule-binding	174..315		63/172 (37%)
		Necessary for interaction with ZFYVE27. /evidence=ECO:0000250\|UniProtKB:P33175	271..361		29/105 (28%)
		Interaction with BICD2. /evidence=ECO:0000269\|PubMed:20386726	353..1032		56/342 (16%)
		Smc	<412..759	CDD:224117	50/283 (18%)
		DUF5401	<630..>902	CDD:375164	12/58 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	906..939
		Globular	907..1032
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	978..1010
KIP2	NP_015170.1	KISc_CENP_E	102..493	CDD:276825	124/354 (35%)
KIP2	NP_015170.1	SMC_prok_B	<445..>698	CDD:274008	77/408 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S2014
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.950