Protein Alignment KIF5A and SMY1

DIOPT Version :9

• Sequence 1: NP_004975.2
• Gene: KIF5A / 3798
• HGNCID: 6323
• Length: 1032
• Species: Homo sapiens
• Sequence 2: NP_012844.1
• Gene: SMY1 / 853783
• SGDID: S000001562
• Length: 656
• Species: Saccharomyces cerevisiae
• Alignment Length: 571
• Identity: 154/571 - (26%)
• Similarity: 268/571 - (46%)
• Gaps: 90/571 - (15%)

Human     5 NNECSIKVLCRFRPLNQAEILRGDKFIPIFQGDDSVVIGGKPYVFDRVFPPNTTQEQVYHACAMQ 69
            |||.:.|:    .|.....:.|.:.  |:.:.....   ...:.||:||..|.|||.|.......
Yeast    42 NNESTFKI----DPYENTVLFRTNN--PLHETTKET---HSTFQFDKVFDANATQEDVQKFLVHP 97

Human    70 IVKDVLAGYNGTIFAYGQTSSGKTHTMEGKLHDPQLMGIIPRIARDIFNHIYSMDENLE-----F 129
            |:.|||.|||||:..||.:.|||::::.|   ..:..||:|.|.:.:|:   ::::|.|     |
Yeast    98 IINDVLNGYNGTVITYGPSFSGKSYSLIG---SKESEGILPNICKTLFD---TLEKNEETKGDSF 156

Human   130 HIKVSYFEIYLDKIRDLLD--VTKTNLSVHEDKNRVPF-VKGCTERFVSSPEEILDVID--EGKS 189
            .:.|..||||::|..|||.  ..:..|.:|...:::.. :|......|.|.|::...|.  :...
Yeast   157 SVSVLAFEIYMEKTYDLLVPLPERKPLKLHRSSSKMDLEIKDICPAHVGSYEDLRSYIQAVQNVG 221

Human   190 NRHVAVTNMNEHSSRSHSIFLINIKQENMETEQKLSGKLYLVDLAGSEKVSKTGAEGAVLDEAKN 254
            || :|..:..|. ||||.:|.::::|.|.:.:...:..||||||.|:||..|........|..|.
Yeast   222 NR-MACGDKTER-SRSHLVFQLHVEQRNRKDDILKNSSLYLVDLHGAEKFDKRTESTLSQDALKK 284

Human   255 INKSLSALGNVISAL----------AEGTKSYVPYRDSKMTRILQDSLGGNCRTTMFICCSPSSY 309
            :|:|:.||.|.:.:|          |:|:.|.. ||:|::|.:|:||||||.:|.:.:.|..|
Yeast   285 LNQSIEALKNTVRSLSMKERDSAYSAKGSHSSA-YRESQLTEVLKDSLGGNRKTKVILTCFLS-- 346

Human   310 NDAETKSTLMFGQRAKTIKNTASVNLELTAEQWKKKYE------KEKEKTKAQKETIAKLEAELS 368
            |...|.|||.||...:.|.|..:.|  .|....|||.:      |.|:.....:..|.|.|.:..
Yeast   347 NVPTTLSTLEFGDSIRQINNKVTDN--TTGLNLKKKMDLFIQDMKIKDDNYVAQINILKAEIDSL 409

Human   369 RWRNGENVPETERLAGEEAALGAELCEETPVNDNSSIVVRIAPEERQKYEEEIRRLYKQL--DDK 431
            :..:.:::||.:    |:..|      |....:|..:.:::         :.|.:|....  :|.
Yeast   410 KSLHNKSLPEDD----EKKML------ENTKKENIKLKLQL---------DSITQLLSSSTNEDP 455

Human   432 DDEINQQ-SQLIEKLKQQMLDQEELLVSTRGDNEKVQRELSHLQSENDAAKDEVKEVLQALEELA 495
            ::.|::: |:::.|..:|:...|.........|.|:|:||.:.:|:.:|.:.....:|:.::
Yeast   456 NNRIDEEVSEILTKRCEQIAQLELSFDRQMNSNSKLQQELEYKKSKEEALESMNVRLLEQIQ--- 517

Human   496 VNYDQKSQEVEEKSQQNQLLVDEL----------SQKVATMLSLESELQRL 536
                .:.:|::|....|.:|..||          |:::.   ||||.::.|
Yeast   518 ----LQEREIQELLTTNAILKGELETHTKLTETRSERIK---SLESSVKEL 561

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
KIF5A	NP_004975.2	KISc_KHC_KIF5	7..327	CDD:276820	106/339 (31%)
		Microtubule-binding	174..315		51/152 (34%)
		Necessary for interaction with ZFYVE27. /evidence=ECO:0000250|UniProtKB:P33175	271..361		32/95 (34%)
		Interaction with BICD2. /evidence=ECO:0000269|PubMed:20386726	353..1032		37/197 (19%)
		Smc	<412..759	CDD:224117	28/138 (20%)
		DUF5401	<630..>902	CDD:375164
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	906..939
		Globular	907..1032
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	978..1010
SMY1	NP_012844.1	KISc_KHC_KIF5	25..364	CDD:276820	108/341 (32%)
		Smc	<254..568	CDD:224117	88/342 (26%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0240
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24115
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.910