DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment KIF5A and kif5aa

DIOPT Version :9

Sequence 1:NP_004975.2 Gene:KIF5A / 3798 HGNCID:6323 Length:1032 Species:Homo sapiens
Sequence 2:NP_001186705.1 Gene:kif5aa / 566086 ZFINID:ZDB-GENE-070912-141 Length:1033 Species:Danio rerio


Alignment Length:1054 Identity:757/1054 - (71%)
Similarity:879/1054 - (83%) Gaps:43/1054 - (4%)


- Green bases have known domain annotations that are detailed below.


Human     1 MAETNNECSIKVLCRFRPLNQAEILRGDKFIPIFQGDDSVVIGGKPYVFDRVFPPNTTQEQVYHA 65
            |.:...||:|||||||||||||||||||||:|.|||||:|:||||.|.||||||.||||||||:.
Zfish     1 MTDAAAECNIKVLCRFRPLNQAEILRGDKFLPTFQGDDTVIIGGKSYAFDRVFPTNTTQEQVYNT 65

Human    66 CAMQIVKDVLAGYNGTIFAYGQTSSGKTHTMEGKLHDPQLMGIIPRIARDIFNHIYSMDENLEFH 130
            ||.|||||||.||||||||||||||||||||||.|||||.||||||||.||||||:|||||||||
Zfish    66 CAKQIVKDVLGGYNGTIFAYGQTSSGKTHTMEGNLHDPQQMGIIPRIAEDIFNHIFSMDENLEFH 130

Human   131 IKVSYFEIYLDKIRDLLDVTKTNLSVHEDKNRVPFVKGCTERFVSSPEEILDVIDEGKSNRHVAV 195
            |||||||||::|||||||||||||||||||||||:||||||||||||||::||||||||||||||
Zfish   131 IKVSYFEIYMEKIRDLLDVTKTNLSVHEDKNRVPYVKGCTERFVSSPEEVMDVIDEGKSNRHVAV 195

Human   196 TNMNEHSSRSHSIFLINIKQENMETEQKLSGKLYLVDLAGSEKVSKTGAEGAVLDEAKNINKSLS 260
            |||||||||||||||||||||::||||||.|||||||||||||||||||.|||||||||||||||
Zfish   196 TNMNEHSSRSHSIFLINIKQEHVETEQKLCGKLYLVDLAGSEKVSKTGAAGAVLDEAKNINKSLS 260

Human   261 ALGNVISALAEGTKSYVPYRDSKMTRILQDSLGGNCRTTMFICCSPSSYNDAETKSTLMFGQRAK 325
            |||||||||||||||:|||||||||||||||||||||||||||||||||||||||||||||||||
Zfish   261 ALGNVISALAEGTKSHVPYRDSKMTRILQDSLGGNCRTTMFICCSPSSYNDAETKSTLMFGQRAK 325

Human   326 TIKNTASVNLELTAEQWKKKYEKEKEKTKAQKETIAKLEAELSRWRNGENVPETERLAGEEAALG 390
            |||||||:||||||||||:||||||||.|:.::::.:||.||.||||||.|||||:...:...| 
Zfish   326 TIKNTASINLELTAEQWKRKYEKEKEKNKSLRDSMQRLELELRRWRNGEKVPETEQTDADVVKL- 389

Human   391 AELCEETPV---------------NDNSSIVVRIAPEERQKYEEEIRRLYKQLDDKDDEINQQSQ 440
             ::.|||.:               :|.|||||||:.|||||||||||:||:||||||||||.|.|
Zfish   390 -DVSEETSLDNEKSCERQRERERDSDTSSIVVRISEEERQKYEEEIRKLYRQLDDKDDEINLQCQ 453

Human   441 LIEKLKQQMLDQEELLVSTRGDNEKVQRELSHLQSENDAAKDEVKEVLQALEELAVNYDQKSQEV 505
            |:||||:|:|||:|||.|||||::|||.||..||:|:::||.||:||||||||||||||||||||
Zfish   454 LVEKLKEQILDQDELLASTRGDSDKVQTELGRLQTESESAKAEVREVLQALEELAVNYDQKSQEV 518

Human   506 EEKSQQNQLLVDELSQKVATMLSLESELQRLQEVSGHQRKRIAEVLNGLMKDLSEFSVIVGNGEI 570
            ||||..|:.|.::||.|:|.::.||:||.::||||..||||||:|||||||||||||.||||||:
Zfish   519 EEKSLHNKQLAEQLSHKMANLMELEAELAQMQEVSSQQRKRIADVLNGLMKDLSEFSSIVGNGEL 583

Human   571 KLPVEISGAIEEEFTVARLYISKIKSEVKSVVKRCRQLENLQVECHRKMEVTGRELSSCQLLISQ 635
            ||||||||||||||||||||||||||||||:|||||||||:|:|||||||.|.||||||||||||
Zfish   584 KLPVEISGAIEEEFTVARLYISKIKSEVKSMVKRCRQLENMQLECHRKMEETSRELSSCQLLISQ 648

Human   636 HEAKIRSLTEYMQSVELKKRHLEESYDSLSDELAKLQAQETVHEVALKDKEPDTQDADEVKKALE 700
            |||||||||||||:||.|||.||::||:||:||..||..|: |...|...|...::||..|.|:.
Zfish   649 HEAKIRSLTEYMQNVEQKKRQLEDNYDALSEELYTLQNSES-HVAELDGGEKADREADGKKAAVR 712

Human   701 LQMESHREAHHRQLARLRDEINEKQKTIDELKDLNQKLQLELEKLQADYEKLKSEEHEKSTKLQE 765
            ..:  |.|:...||:||||||||||:.||||.|.||.|:|||..:::.:..||.::..||..|::
Zfish   713 PAL--HAESRQTQLSRLRDEINEKQRLIDELTDKNQALELELAHVRSSFSNLKLQDDSKSACLEQ 775

Human   766 LTFLYERHEQSKQDLKGLEETVARELQTLHNLRKLFVQDVTTRVKKSAEMEPEDSGGIHSQKQKI 830
            ::|..||||||||||||||||||||||||||||||||||:|||||||:|:.|:||||.::|||||
Zfish   776 MSFQQERHEQSKQDLKGLEETVARELQTLHNLRKLFVQDLTTRVKKSSEIGPDDSGGSNTQKQKI 840

Human   831 SFLENNLEQLTKVHKQLVRDNADLRCELPKLEKRLRATAERVKALEGALKEAKEGAMKDKRRYQQ 895
            |||||||:||||||||||||||||||||||||||||:|||||:|||.|||:||:|||.|:|||||
Zfish   841 SFLENNLDQLTKVHKQLVRDNADLRCELPKLEKRLRSTAERVRALETALKDAKQGAMNDRRRYQQ 905

Human   896 EVDRIKEAVRYKSSGKRGHSAQIAKPVRPGHY-PASSPTNPYGTR-SPECISYTNSLF---QNYQ 955
            ||:||::|:|.:...:|.::|||||||||||: .|:|||:...|| |....||:|:.|   :..:
Zfish   906 EVERIRDAMRLRYPLRRPNAAQIAKPVRPGHHVTATSPTSFSVTRASKPATSYSNARFLQDEKME 970

Human   956 NLYLQATP--SSTSDMYFANSCTSSGATSSGGPLASYQKANMDNGNATDINDNRSDLPCGYEAED 1018
            |.....|.  |:...:...:||          ||      :::|||:|||||||||:.||...:|
Zfish   971 NSQKTNTVGYSTVRSIDILSSC----------PL------DVENGNSTDINDNRSDVHCGSMVDD 1019

Human  1019 QAKLFPLHQETAAS 1032
            .::::.:.||||||
Zfish  1020 ASRVYIMQQETAAS 1033

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
KIF5ANP_004975.2 KISc_KHC_KIF5 7..327 CDD:276820 293/319 (92%)
Microtubule-binding 174..315 133/140 (95%)
Necessary for interaction with ZFYVE27. /evidence=ECO:0000250|UniProtKB:P33175 271..361 80/89 (90%)
Interaction with BICD2. /evidence=ECO:0000269|PubMed:20386726 353..1032 436/700 (62%)
Smc <412..759 CDD:224117 240/346 (69%)
DUF5401 <630..>902 CDD:375164 186/271 (69%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 906..939 16/33 (48%)
Globular 907..1032 49/131 (37%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 978..1010 13/31 (42%)
kif5aaNP_001186705.1 KISc_KHC_KIF5 7..327 CDD:276820 293/319 (92%)
KISc 9..334 CDD:214526 298/324 (92%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C194326391
Domainoid 1 1.000 848 1.000 Domainoid score I705
eggNOG 00.000 Not matched by this tool.
Hieranoid 1 1.000 - -
Homologene 1 1.000 - - H55861
Inparanoid 1 1.050 1446 1.000 Inparanoid score I1038
NCBI 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG52972
OrthoDB 1 1.010 - - D1334528at2759
OrthoFinder 1 1.000 - - FOG0000669
OrthoInspector 1 1.000 - - oto48163
orthoMCL 1 0.900 - - OOG6_100344
Panther 1 1.100 - - LDO PTHR24115
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X952
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 1 1.500 - -
1414.410

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