DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment KIF5A and cmet

DIOPT Version :9

Sequence 1:	NP_004975.2	Gene:	KIF5A / 3798	HGNCID:	6323	Length:	1032	Species:	Homo sapiens
Sequence 2:	NP_524993.3	Gene:	cmet / 53561	FlyBaseID:	FBgn0040232	Length:	2189	Species:	Drosophila melanogaster

Alignment Length:	1106	Identity:	295/1106 - (26%)
Similarity:	469/1106 - (42%)	Gaps:	309/1106 - (27%)

- Green bases have known domain annotations that are detailed below.

Human     6 NECSIKVLCRFRP-------LNQAEILRGDKFIPIFQGDDSVVIGGKPYVFDRVFPPNTTQEQVY 63
            |..||:|..:.||       |.|.:..|.     |...|..    .:|||||.||....:.::|:
  Fly     5 NASSIQVCIKVRPCEPGLTSLWQVKERRS-----IHLADSH----AEPYVFDYVFDEGASNQEVF 60

Human    64 HACAMQIVKDVLAGYNGTIFAYGQTSSGKTHTMEGKLHDPQLMGIIPRIARDIFNHIYSMDENLE 128
            ...|..||...:.|:|||||||||||||||:||.|   |.|..|::...|::||..|.|..|. :
  Fly    61 DRMAKHIVHACMQGFNGTIFAYGQTSSGKTYTMMG---DEQNPGVMVLAAKEIFQQISSETER-D 121

Human   129 FHIKVSYFEIYLDKIRDLLDVTKTNLSVHEDKNRVPFVKGCTERFVSSPEEILDVIDEGKSNRHV 193
            |.::|.|.|||.:||.|||:....:|.:||..|.:..| .|.|..::|..::|.::..|...|.|
  Fly   122 FLLRVGYIEIYNEKIYDLLNKKNQDLKIHESGNGIVNV-NCEECIITSEVDLLRLLCLGNKERTV 185

Human   194 AVTNMNEHSSRSHSIFLINI---KQENMETEQKLSGKLYLVDLAGSEKVSKTGAEGAVLDEAKNI 255
            ..|||||.|||||:||.|.|   |.::.:.:..:...|.||||||||:..:|||.||.|.|..:|
  Fly   186 GETNMNERSSRSHAIFKIIIESRKSDHSDDDAVIQSVLNLVDLAGSERADQTGARGARLKEGGHI 250

Human   256 NKSLSALGNVISALAEGTKS-YVPYRDSKMTRILQDSLGGNCRTTMFICCSPSSYNDAETKSTLM 319
            ||||..|.|||.:|:|...: :..|||||:|||||.|||||..|::.....||...  |::|||.
  Fly   251 NKSLLFLSNVIKSLSENADNRFTNYRDSKLTRILQASLGGNAFTSIICTIKPSIME--ESQSTLS 313

Human   320 FGQRAKTIKNTASVNLELTAEQWKKKYEK----------EKEKTKAQKETIAKLEAEL------- 367
            |..|||.|:....||..::.....|:.|:          |:|:....::.:..||.::
  Fly   314 FATRAKKIRIKPQVNEMVSDATMMKRLEREIKVLKDKLAEEERKNENQQKVEHLERQIKHDMHKI 378

Human   368 ------------------------------------------------------------SRWRN 372
                                                                        .||
  Fly   379 ICGHSLSDKGQQKRRRTWCPTASGSHLELAETGTTEDRIDQFPKVSHLPKPVFFHTSNAGKRW-- 441

Human   373 GENVPETERLAG-----------EEAALGAELCE-------------------ETPVNDNSSIVV 407
             :|:|:|..:.|           .|..|.||..:                   :.|:.....:..
  Fly   442 -DNIPKTINILGSLDIGTESNSISEEFLPAECIDFGSPRPDVLKPMLTIRQLPDLPLTPKGPLTT 505

Human   408 RIAPEERQKYE-------------EEIRRLYKQLDD---KDDEINQQSQLIEKLKQQMLDQEELL 456
            ....:|.|..:             ||::.|.::|.:   :.|.:.|:| |.||.:...|::|  :
  Fly   506 DKIKKEIQDLQMFTSLEKHFEVECEEVQGLKEKLAEVTAQRDNLEQES-LAEKERYDALEKE--V 567

Human   457 VSTRGDNEKVQRELSHLQSENDAAKDEVKEVLQALEELAVNYDQKSQEVEEKSQQNQLLVDELSQ 521
            .|.|.|||....::|.|:.:....|..:: :::...::||..:   .|.|...:.::|.||:|
  Fly   568 TSLRADNEAANSKISELEEKLSTLKQTMR-IMEVENQVAVGLE---FEFEAHKKSSKLRVDDL-- 626

Human   522 KVATMLSLESELQRLQEVSGHQRKRIAEVLNGLMKDLSEFSVIVGNGEIKLPVEISGAIEEEFTV 586
             ::.:|..||.::.||           :.|:.|.:|:...|   ..|.:     :|.|.|:|...
  Fly   627 -LSALLEKESTIESLQ-----------KSLDNLTRDVLRNS---KEGHM-----LSIAPEQEDIA 671

Human   587 ARLYISKIKSEVKSVVKRCRQLENLQVECHRKMEVTGRELSSCQLLISQHEAKIRSLTEYMQSVE 651
            .           .|:..:|.:||.|..:...|.       :||:  ..|...:|.|:.:.::|||
  Fly   672 G-----------DSICNKCEELEKLIADLESKK-------NSCE--CDQLRLEIVSVRDKLESVE 716

Human   652 -------------------LKKR---------HLEESYDSLSDELAKLQAQE----TVHE--VAL 682
                               |.|.         .|:|.||:|..:   .|||:    |:||  ..:
  Fly   717 SAFNLASSEIIQKATDCERLSKELSTSQNAFGQLQERYDALDQQ---WQAQQAGITTLHEKHEHV 778

Human   683 KDKEPDTQDADEVKKALELQMESH-REAHHRQLARLRDEINEKQKTIDELKDLNQKLQ------L 740
            ::|....|:..|       |:||. |.|...:..||:   |:..|...::..||::|:      .
  Fly   779 QEKYQKLQEEYE-------QLESRARSASSAEFQRLQ---NDNTKFQADIASLNERLEEAQNMLT 833

Human   741 ELEKLQADYEKLKSEEHEKSTKLQELTFLYERHEQ-----SKQDLKGLEETVARELQTLHNLRKL 800
            |::..::..|||:.:.||.:.|::||...:|..::     |.|.::.::|..|        ||:.
  Fly   834 EVQNSESTVEKLRIQNHELTAKIKELETNFEEMQREYDCLSNQLMESVQENDA--------LREE 890

Human   801 FVQDVTTRVKKSAEMEPEDSGGIHS----QKQKISF------LENNLEQLTKVH----KQLVRDN 851
            ..|..|:.|::|..     |.||.|    |||.|:.      |..:::|:...|    .:|.|.|
  Fly   891 IKQRPTSHVEESMR-----SSGISSDFDEQKQDINLLHQFVQLSESVQQIELQHHSGISRLFRAN 950

Human   852 ADLRCELPKLEKRLRATAERVK---------------ALEGALKEAKEGAMKDKRRYQQEVDRIK 901
               :.:|.:.|..|:...|..:               .|:|.||..:   .:.||..|:.||..:
  Fly   951 ---QMKLDQSEPGLKLCLESAEYIEEDNRQSDATEPICLKGFLKRHR---FQIKRLSQEHVDMGE 1009

Human   902 E 902
            |
  Fly  1010 E 1010

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
KIF5A	NP_004975.2	KISc_KHC_KIF5	7..327	CDD:276820	140/330 (42%)
		Microtubule-binding	174..315		66/144 (46%)
		Necessary for interaction with ZFYVE27. /evidence=ECO:0000250\|UniProtKB:P33175	271..361		34/100 (34%)
		Interaction with BICD2. /evidence=ECO:0000269\|PubMed:20386726	353..1032		147/738 (20%)
		Smc	<412..759	CDD:224117	91/403 (23%)
		DUF5401	<630..>902	CDD:375164	81/346 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	906..939
		Globular	907..1032
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	978..1010
cmet	NP_524993.3	KISc	8..328	CDD:214526	141/335 (42%)
		Motor_domain	8..321	CDD:277568	140/328 (43%)
		Smc	<680..1449	CDD:224117	88/372 (24%)
		TMPIT	779..>867	CDD:285135	25/97 (26%)
		Smc	1042..1910	CDD:224117
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000669
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.910