Protein Alignment KIF5A and Kif3C

DIOPT Version :10

• Sequence 1: NP_004975.2
• Gene: KIF5A / 3798
• HGNCID: 6323
• Length: 1032
• Species: Homo sapiens
• Sequence 2: NP_651939.4
• Gene: Kif3C / 43820
• FlyBaseID: FBgn0039925
• Length: 649
• Species: Drosophila melanogaster
• Alignment Length: 561
• Identity: 181/561 - (32%)
• Similarity: 274/561 - (48%)
• Gaps: 63/561 - (11%)

Human     9 SIKVLCRFRPLNQAE-------ILRGDKFIPIFQGDDSVVIGGKPYVFDRVFPPNTTQEQVYHAC 66
            :|||:.|.||:||.|       |:..::|........:.:...|.::||.|:...|..|.:|...
  Fly     4 NIKVVVRCRPMNQTEKERNCQNIVEINEFAVSVTNPSARISQQKKFIFDSVYNMKTDTEVIYDEM 68

Human    67 AMQIVKDVLAGYNGTIFAYGQTSSGKTHTMEGKLHDPQLMGIIPRIARDIFNHIY---SMDENLE 128
            ...:|:..:.||||||||||||..||||||:|..:.....||||:    .|:||:   ||..|:.
  Fly    69 CYSLVESTIEGYNGTIFAYGQTGCGKTHTMQGDENFSNSTGIIPK----CFDHIFERISMTTNVR 129

Human   129 FHIKVSYFEIYLDKIRDLLDVTKTNLSVHEDKNRVP----FVKGCTERFVSSPEEILDVIDEGKS 189
            :...|:|.|||.::|||||:..:....::.....:|    .|...|.:.|.:..:..|.:..|..
  Fly   130 YLALVTYLEIYNERIRDLLNKNENTNVINHFLKELPGIGVSVPTLTTQPVVNANQCYDWLHFGNK 194

Human   190 NRHVAVTNMNEHSSRSHSIFLINIKQE---NMETEQKLS----GKLYLVDLAGSEKVSKTGAEGA 247
            ||..|.|.||::|||||:||.|.::|.   |........    |||.||||||||:..||||:|.
  Fly   195 NRVTAATLMNKNSSRSHTIFTITLEQSPFLNSIGSDAFGGICRGKLSLVDLAGSERQRKTGAQGD 259

Human   248 VLDEAKNINKSLSALGNVISALAEGTKSYVPYRDSKMTRILQDSLGGNCRTTMFICCSPSSYNDA 312
            .|.||..||.||||||||||:|.:|...:||:||||:||:||||||||.:|.|..|.||:..:..
  Fly   260 RLKEASQINLSLSALGNVISSLVDGKAKHVPFRDSKLTRLLQDSLGGNTKTLMISCISPTDIHYD 324

Human   313 ETKSTLMFGQRAKTIKNTASVNLELTAEQWKKKYEKE----KEKTKAQKETIAKLEAELSRWRNG 373
            ||.|||.:..|||.|.|...:| |...:...::|:.|    |...:..::.|.|        .|.
  Fly   325 ETISTLRYASRAKNISNKPKIN-EDPKDARLRQYQNEILYLKRMLQESQQIINK--------NND 380

Human   374 ENVPETERLAGEEAALGAELCEETPVNDNSSI-VVRIAPEERQKYEEEIRRLYKQ----LDDKDD 433
            .|......|         ::.:.|.:|...:: ::.:....:..::.....|.|.    :..|::
  Fly   381 PNKIIKSPL---------KIIQHTNMNSTKNVQIIDLGRNCKASFKTNNSILTKPNFPLIQSKEE 436

Human   434 EINQQSQLIEKLKQQMLDQE-----ELLVSTRGDNEKVQRELSHLQSENDAAKDEVKEVLQALEE 493
            ...|....|:.:|:.::..|     ||...........||.||.:.......|.|.:::||.
  Fly   437 VQLQARSRIDLIKRSLIGGERIHDFELKEKHMARKYAAQRHLSAIAIALSRVKCEDRDLLQG--- 498

Human   494 LAVNYDQKSQEVEEKSQQNQLLVDELSQKVATMLSLESELQ 534
               :|...:||::.|:...:...:::......:..|.||.|
  Fly   499 ---HYATITQEIDIKNDYIRKCKEKIKMLEMEVSDLNSEFQ 536

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
KIF5A	NP_004975.2	KISc_KHC_KIF5	7..327	CDD:276820	142/338 (42%)
		Microtubule-binding	174..315		74/147 (50%)
		Necessary for interaction with ZFYVE27. /evidence=ECO:0000250|UniProtKB:P33175	271..361		37/93 (40%)
		Interaction with BICD2. /evidence=ECO:0000269|PubMed:20386726	353..1032		32/192 (17%)
		PRK03918	<409..920	CDD:235175	25/135 (19%)
		Khc_CBD_cc	832..901	CDD:467880
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	906..939
		Globular	907..1032
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	978..1010
Kif3C	NP_651939.4	Motor_domain	3..339	CDD:473979	142/338 (42%)