Protein Alignment KIF5A and Khc

DIOPT Version :10

• Sequence 1: NP_004975.2
• Gene: KIF5A / 3798
• HGNCID: 6323
• Length: 1032
• Species: Homo sapiens
• Sequence 2: NP_476590.1
• Gene: Khc / 36810
• FlyBaseID: FBgn0001308
• Length: 975
• Species: Drosophila melanogaster
• Alignment Length: 950
• Identity: 568/950 - (59%)
• Similarity: 722/950 - (76%)
• Gaps: 41/950 - (4%)

Human     7 ECSIKVLCRFRPLNQAEILRGDKFIPIFQG---DDSVVIGGKPYVFDRVFPPNTTQEQVYHACAM 68
            |.||||:|||||||.:|...|.||:..|..   ::.:.|.||.|:||:||.||.:||:||:..|.
  Fly    10 EDSIKVVCRFRPLNDSEEKAGSKFVVKFPNNVEENCISIAGKVYLFDKVFKPNASQEKVYNEAAK 74

Human    69 QIVKDVLAGYNGTIFAYGQTSSGKTHTMEGKLHDPQLMGIIPRIARDIFNHIYSMDENLEFHIKV 133
            .||.||||||||||||||||||||||||||.:.|....||||||..|||||||:|:.||||||||
  Fly    75 SIVTDVLAGYNGTIFAYGQTSSGKTHTMEGVIGDSVKQGIIPRIVNDIFNHIYAMEVNLEFHIKV 139

Human   134 SYFEIYLDKIRDLLDVTKTNLSVHEDKNRVPFVKGCTERFVSSPEEILDVIDEGKSNRHVAVTNM 198
            ||:|||:|||||||||:|.||||||||||||:|||.|||||||||::.:||:|||||||:|||||
  Fly   140 SYYEIYMDKIRDLLDVSKVNLSVHEDKNRVPYVKGATERFVSSPEDVFEVIEEGKSNRHIAVTNM 204

Human   199 NEHSSRSHSIFLINIKQENMETEQKLSGKLYLVDLAGSEKVSKTGAEGAVLDEAKNINKSLSALG 263
            |||||||||:||||:||||:|.::||||||||||||||||||||||||.||||||||||||||||
  Fly   205 NEHSSRSHSVFLINVKQENLENQKKLSGKLYLVDLAGSEKVSKTGAEGTVLDEAKNINKSLSALG 269

Human   264 NVISALAEGTKSYVPYRDSKMTRILQDSLGGNCRTTMFICCSPSSYNDAETKSTLMFGQRAKTIK 328
            |||||||:|.|:::||||||:|||||:|||||.|||:.|||||:|:|::||||||.||:||||:|
  Fly   270 NVISALADGNKTHIPYRDSKLTRILQESLGGNARTTIVICCSPASFNESETKSTLDFGRRAKTVK 334

Human   329 NTASVNLELTAEQWKKKYEKEKEKTKAQKETIAKLEAELSRWRNGENVPETERL----------- 382
            |...||.|||||:||::|||||||....|..:.|||.||:|||.||.|...|::
  Fly   335 NVVCVNEELTAEEWKRRYEKEKEKNARLKGKVEKLEIELARWRAGETVKAEEQINMEDLMEASTP 399

Human   383 ---------AGEEAALGAELCEETPVNDNSSIVVRIAPEERQKYEEEIRRLYKQLDDKDDEINQQ 438
                     |..||||.|:  .....|.::|:.|    .|:.:...|..|||:||||||:|||||
  Fly   400 NLEVEAAQTAAAEAALAAQ--RTALANMSASVAV----NEQARLATECERLYQQLDDKDEEINQQ 458

Human   439 SQLIEKLKQQMLDQEELLVSTRGDNEKVQRELSHLQSENDAAKDEVKEVLQALEELAVNYDQKSQ 503
            ||..|:||:|:::||||:.:.|.:.|.:|.|::.:|.||::||:|||||||||||||||||||||
  Fly   459 SQYAEQLKEQVMEQEELIANARREYETLQSEMARIQQENESAKEEVKEVLQALEELAVNYDQKSQ 523

Human   504 EVEEKSQQNQLLVDELSQKVATMLSLESELQRLQEVSGHQRKRIAEVLNGLMKDLSEFSVIVGNG 568
            |::.|::....|.:||.||.:...:..:|||:|:::|.||:|||.|:|..|::||.|....:..|
  Fly   524 EIDNKNKDIDALNEELQQKQSVFNAASTELQQLKDMSSHQKKRITEMLTNLLRDLGEVGQAIAPG 588

Human   569 EIKLPVEIS-------GAIEEEFTVARLYISKIKSEVKSVVKRCRQLENLQVECHRKMEVTGREL 626
            |..:.:::|       ..:||:||:|||:|||:|:|.|::.:||..:|..|.:.::|:....::|
  Fly   589 ESSIDLKMSALAGTDASKVEEDFTMARLFISKMKTEAKNIAQRCSNMETQQADSNKKISEYEKDL 653

Human   627 SSCQLLISQHEAKIRSLTEYMQSVELKKRHLEESYDSLSDELAKLQAQETVHEVALKDKEPDTQD 691
            ...:||||||||:::||.|.|:..|.|||.|||..|||.:|.|||:|.|.|..|..::|    |.
  Fly   654 GEYRLLISQHEARMKSLQESMREAENKKRTLEEQIDSLREECAKLKAAEHVSAVNAEEK----QR 714

Human   692 ADEVKKALELQMESHREAHHRQLARLRDEINEKQKTIDELKDLNQKLQLELEKLQADYEKLKSEE 756
            |:|::...:.||:..||||.||::.|||||..||..:||:||::|||.|..:::.|||||::.|:
  Fly   715 AEELRSMFDSQMDELREAHTRQVSELRDEIAAKQHEMDEMKDVHQKLLLAHQQMTADYEKVRQED 779

Human   757 HEKSTKLQELTFLYERHEQSKQDLKGLEETVARELQTLHNLRKLFVQDVTTRVKKS-AEMEPEDS 820
            .|||::||.:....||.||:::||||||:|||:|||||||||||||||:..|::|: ...|.|:.
  Fly   780 AEKSSELQNIILTNERREQARKDLKGLEDTVAKELQTLHNLRKLFVQDLQQRIRKNVVNEESEED 844

Human   821 GGIHSQKQKISFLENNLEQLTKVHKQLVRDNADLRCELPKLEKRLRATAERVKALEGALKEAKEG 885
            ||..:||||||||||||:||||||||||||||||||||||||||||.|.|||||||.||||||||
  Fly   845 GGSLAQKQKISFLENNLDQLTKVHKQLVRDNADLRCELPKLEKRLRCTMERVKALETALKEAKEG 909

Human   886 AMKDKRRYQQEVDRIKEAVRYKSSGKRGHSAQIAKPVRPG 925
            ||:|::|||.||||||||||.|..|:||..||||||:|.|
  Fly   910 AMRDRKRYQYEVDRIKEAVRQKHLGRRGPQAQIAKPIRSG 949

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
KIF5A	NP_004975.2	KISc_KHC_KIF5	7..327	CDD:276820	240/322 (75%)
		Microtubule-binding	174..315		113/140 (81%)
		Necessary for interaction with ZFYVE27. /evidence=ECO:0000250|UniProtKB:P33175	271..361		59/89 (66%)
		Interaction with BICD2. /evidence=ECO:0000269|PubMed:20386726	353..1032		308/600 (51%)
		PRK03918	<409..920	CDD:235175	282/518 (54%)
		Khc_CBD_cc	832..901	CDD:467880	60/68 (88%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	906..939		11/19 (58%)
		Globular	907..1032		11/18 (61%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	978..1010
Khc	NP_476590.1	KISc_KHC_KIF5	10..333	CDD:276820	240/322 (75%)
		Smc	<341..>807	CDD:440809	213/475 (45%)
		Khc_CBD_cc	856..925	CDD:467880	60/68 (88%)