DRSC/TRiP Functional Genomics Resources

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Protein Alignment KIF5A and klp3

DIOPT Version :9

Sequence 1:NP_004975.2 Gene:KIF5A / 3798 HGNCID:6323 Length:1032 Species:Homo sapiens
Sequence 2:NP_594686.1 Gene:klp3 / 2542195 PomBaseID:SPAC1834.07 Length:554 Species:Schizosaccharomyces pombe


Alignment Length:570 Identity:226/570 - (39%)
Similarity:323/570 - (56%) Gaps:61/570 - (10%)


- Green bases have known domain annotations that are detailed below.


Human     9 SIKVLCRFRPLNQAE-ILRGDKFI-PIFQGDDSVVIGGKPY----VFDRVFPPNTTQEQVYHACA 67
            ||||:||.||.||.| .|.|:..| |:  .|.:|.|....|    ||||||.|::||..::....
pombe     3 SIKVVCRIRPTNQLEQDLGGNNVIYPL--NDSTVHIETSDYSGNFVFDRVFHPSSTQNDIFSYSI 65

Human    68 MQIVKDVLAGYNGTIFAYGQTSSGKTHTMEGKLHDPQLMGIIPRIARDIFNHIYSMDENLEFHIK 132
            ...|.|:..|||||:.|||||.||||:||.|..::.:..|:.||:.|.||:.|.......|:.:|
pombe    66 ESTVDDLFLGYNGTVLAYGQTGSGKTYTMMGIENNFEKEGMTPRMLRRIFDKIRDSPSTTEYEVK 130

Human   133 VSYFEIYLDKIRDLLDVTKTNLSVHEDKNRVPFVKGCTERFVSSPEEILDVIDEGKSNRHVAVTN 197
            |||.|||::||.|||......|:|||||.:..:|:|....:|||..|.||::::|..:|.||.|:
pombe   131 VSYMEIYMEKIHDLLSEKNDRLTVHEDKLQGVYVQGLKTIYVSSETEALDILNKGMGSRAVASTS 195

Human   198 MNEHSSRSHSIFLINIKQENMETEQKLSGKLYLVDLAGSEKVSKTGAEGAVLDEAKNINKSLSAL 262
            ||..||||||||::.:.|.:.|:.:...|:|:||||||||.|.|:||.|..|:|||.||:|||.|
pombe   196 MNAQSSRSHSIFVLEVVQTDTESGETRRGRLFLVDLAGSESVGKSGAVGQTLEEAKKINRSLSTL 260

Human   263 GNVISALAEGTKSYVPYRDSKMTRILQDSLGGNCRTTMFICCSPSSYNDAETKSTLMFGQRAKTI 327
            |.||::|.:...|:|||||||:||||::|||||.|||:.|.|||.|||..||.|||.||.|||:|
pombe   261 GMVINSLTDSKLSHVPYRDSKLTRILKESLGGNSRTTLIINCSPDSYNATETLSTLRFGHRAKSI 325

Human   328 KNTASVNLELTAEQWKKKYEKEKEKTKAQKETI--AKLEAEL-------SRWRNGE------NVP 377
            ||.|.||.||:.::.|::....|:   |....:  |::...|       :.| :||      |:.
pombe   326 KNKAVVNSELSVDEMKRQLYIYKD---ALSRCVCGARINNNLDYNNCHSNVW-SGEHSLTLSNLA 386

Human   378 ETERLAGEEAALGAELCEETPVNDNSSIVVRIAPEERQKYE-EEIRRLY--KQLDDKDDEINQQS 439
            |...|...|...|....:|:..:.:.|.|..|   .|..:: :.|.|||  .||     |:.|:.
pombe   387 EKSNLKEAEIIQGNRTIQESNNDRDESTVASI---HRHNFDSDSINRLYAEAQL-----ELKQRD 443

Human   440 QLIEKLKQQMLDQEELLVSTRGDNEKVQREL--SHLQSENDAAKDEVKEVLQALEELAVNYDQKS 502
            .::...|||:.|    |::..||.::...||  :|..:.|..|.:.:.      ::.....:||.
pombe   444 GVLSSTKQQLSD----LMTALGDAQERYVELVKNHRVNSNLTANNSLN------DKPGFTIEQKD 498

Human   503 QEVEEKSQQNQLLVDELSQKVATMLSLESELQRLQEVSGHQRKRIAEVLN 552
            :.....:::|..|     ||::|   |:|.|..|..|   |||.|..:::
pombe   499 KNFSINNERNNFL-----QKLST---LDSSLAALVNV---QRKLIKALIS 537

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
KIF5ANP_004975.2 KISc_KHC_KIF5 7..327 CDD:276820 164/323 (51%)
Microtubule-binding 174..315 80/140 (57%)
Necessary for interaction with ZFYVE27. /evidence=ECO:0000250|UniProtKB:P33175 271..361 48/91 (53%)
Interaction with BICD2. /evidence=ECO:0000269|PubMed:20386726 353..1032 52/220 (24%)
Smc <412..759 CDD:224117 37/146 (25%)
DUF5401 <630..>902 CDD:375164
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 906..939
Globular 907..1032
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 978..1010
klp3NP_594686.1 KIP1 1..546 CDD:227392 226/570 (40%)
KISc_KHC_KIF5 1..325 CDD:276820 164/323 (51%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Domainoid 1 1.000 287 1.000 Domainoid score I337
eggNOG 1 0.900 - - E2759_KOG0240
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 328 1.000 Inparanoid score I618
OMA 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0000669
OrthoInspector 1 1.000 - - otm53885
orthoMCL 1 0.900 - - OOG6_100344
Panther 1 1.100 - - O PTHR24115
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R2595
SonicParanoid 1 1.000 - - X952
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
1110.890

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