DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment KIF5A and Kif5a

DIOPT Version :9

Sequence 1:	NP_004975.2	Gene:	KIF5A / 3798	HGNCID:	6323	Length:	1032	Species:	Homo sapiens
Sequence 2:	NP_001034089.1	Gene:	Kif5a / 16572	MGIID:	109564	Length:	1027	Species:	Mus musculus

Alignment Length:	1032	Identity:	1008/1032 - (97%)
Similarity:	1022/1032 - (99%)	Gaps:	5/1032 - (0%)

- Green bases have known domain annotations that are detailed below.

Human     1 MAETNNECSIKVLCRFRPLNQAEILRGDKFIPIFQGDDSVVIGGKPYVFDRVFPPNTTQEQVYHA 65
            ||||||||||||||||||||||||||||||||||||||||:||||||||||||||||||||||||
Mouse     1 MAETNNECSIKVLCRFRPLNQAEILRGDKFIPIFQGDDSVIIGGKPYVFDRVFPPNTTQEQVYHA 65

Human    66 CAMQIVKDVLAGYNGTIFAYGQTSSGKTHTMEGKLHDPQLMGIIPRIARDIFNHIYSMDENLEFH 130
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse    66 CAMQIVKDVLAGYNGTIFAYGQTSSGKTHTMEGKLHDPQLMGIIPRIARDIFNHIYSMDENLEFH 130

Human   131 IKVSYFEIYLDKIRDLLDVTKTNLSVHEDKNRVPFVKGCTERFVSSPEEILDVIDEGKSNRHVAV 195
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse   131 IKVSYFEIYLDKIRDLLDVTKTNLSVHEDKNRVPFVKGCTERFVSSPEEILDVIDEGKSNRHVAV 195

Human   196 TNMNEHSSRSHSIFLINIKQENMETEQKLSGKLYLVDLAGSEKVSKTGAEGAVLDEAKNINKSLS 260
            ||||||||||||||||||||||:||||||||||||||||||||||||||||||||||||||||||
Mouse   196 TNMNEHSSRSHSIFLINIKQENVETEQKLSGKLYLVDLAGSEKVSKTGAEGAVLDEAKNINKSLS 260

Human   261 ALGNVISALAEGTKSYVPYRDSKMTRILQDSLGGNCRTTMFICCSPSSYNDAETKSTLMFGQRAK 325
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse   261 ALGNVISALAEGTKSYVPYRDSKMTRILQDSLGGNCRTTMFICCSPSSYNDAETKSTLMFGQRAK 325

Human   326 TIKNTASVNLELTAEQWKKKYEKEKEKTKAQKETIAKLEAELSRWRNGENVPETERLAGEEAALG 390
            ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||::|||
Mouse   326 TIKNTASVNLELTAEQWKKKYEKEKEKTKAQKETIAKLEAELSRWRNGENVPETERLAGEDSALG 390

Human   391 AELCEETPVNDNSSIVVRIAPEERQKYEEEIRRLYKQLDDKDDEINQQSQLIEKLKQQMLDQEEL 455
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse   391 AELCEETPVNDNSSIVVRIAPEERQKYEEEIRRLYKQLDDKDDEINQQSQLIEKLKQQMLDQEEL 455

Human   456 LVSTRGDNEKVQRELSHLQSENDAAKDEVKEVLQALEELAVNYDQKSQEVEEKSQQNQLLVDELS 520
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse   456 LVSTRGDNEKVQRELSHLQSENDAAKDEVKEVLQALEELAVNYDQKSQEVEEKSQQNQLLVDELS 520

Human   521 QKVATMLSLESELQRLQEVSGHQRKRIAEVLNGLMKDLSEFSVIVGNGEIKLPVEISGAIEEEFT 585
            |||||||||||||||||||||||||||||||||||:|||||||||||||||||||||||||||||
Mouse   521 QKVATMLSLESELQRLQEVSGHQRKRIAEVLNGLMRDLSEFSVIVGNGEIKLPVEISGAIEEEFT 585

Human   586 VARLYISKIKSEVKSVVKRCRQLENLQVECHRKMEVTGRELSSCQLLISQHEAKIRSLTEYMQSV 650
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||:|
Mouse   586 VARLYISKIKSEVKSVVKRCRQLENLQVECHRKMEVTGRELSSCQLLISQHEAKIRSLTEYMQTV 650

Human   651 ELKKRHLEESYDSLSDELAKLQAQETVHEVALKDKEPDTQDADEVKKALELQMESHREAHHRQLA 715
            |||||||||||||||||||:|||.||||||||||||||||||:|||||||||||:||||||||||
Mouse   651 ELKKRHLEESYDSLSDELARLQAHETVHEVALKDKEPDTQDAEEVKKALELQMENHREAHHRQLA 715

Human   716 RLRDEINEKQKTIDELKDLNQKLQLELEKLQADYEKLKSEEHEKSTKLQELTFLYERHEQSKQDL 780
            |||||||||||||||||||||||||||||||||||:||:||:|||.|||||||||||||||||||
Mouse   716 RLRDEINEKQKTIDELKDLNQKLQLELEKLQADYERLKNEENEKSAKLQELTFLYERHEQSKQDL 780

Human   781 KGLEETVARELQTLHNLRKLFVQDVTTRVKKSAEMEPEDSGGIHSQKQKISFLENNLEQLTKVHK 845
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse   781 KGLEETVARELQTLHNLRKLFVQDVTTRVKKSAEMEPEDSGGIHSQKQKISFLENNLEQLTKVHK 845

Human   846 QLVRDNADLRCELPKLEKRLRATAERVKALEGALKEAKEGAMKDKRRYQQEVDRIKEAVRYKSSG 910
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse   846 QLVRDNADLRCELPKLEKRLRATAERVKALEGALKEAKEGAMKDKRRYQQEVDRIKEAVRYKSSG 910

Human   911 KRGHSAQIAKPVRPGHYPASSPTNPYGTRSPECISYTNSLFQNYQNLYLQATPSSTSDMYFANSC 975
            ||||||||||||||||||||||||||||||||||||||:||||||||:|||.||||||||||
Mouse   911 KRGHSAQIAKPVRPGHYPASSPTNPYGTRSPECISYTNNLFQNYQNLHLQAAPSSTSDMYFA--- 972

Human   976 TSSGATSSGGPLASYQKANMDNGNATDINDNRSDLPCGYEAEDQAKLFPLHQETAAS 1032
             ||||||. .|||||||||||||||||||||||||||||||||||||||||||||||
Mouse   973 -SSGATSV-APLASYQKANMDNGNATDINDNRSDLPCGYEAEDQAKLFPLHQETAAS 1027

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
KIF5A	NP_004975.2	KISc_KHC_KIF5	7..327	CDD:276820	317/319 (99%)
		Microtubule-binding	174..315		139/140 (99%)
		Necessary for interaction with ZFYVE27. /evidence=ECO:0000250\|UniProtKB:P33175	271..361		89/89 (100%)
		Interaction with BICD2. /evidence=ECO:0000269\|PubMed:20386726	353..1032		656/678 (97%)
		Smc	<412..759	CDD:224117	337/346 (97%)
		DUF5401	<630..>902	CDD:375164	262/271 (97%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	906..939		32/32 (100%)
		Globular	907..1032		114/124 (92%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	978..1010		28/31 (90%)
Kif5a	NP_001034089.1	KISc_KHC_KIF5	7..327	CDD:276820	317/319 (99%)
		Microtubule-binding	174..315		139/140 (99%)
		Necessary for interaction with ZFYVE27. /evidence=ECO:0000269\|PubMed:21976701	271..361		89/89 (100%)
		Interaction with BICD2. /evidence=ECO:0000250\|UniProtKB:Q12840	353..1027		656/678 (97%)
		Smc	<412..759	CDD:224117	337/346 (97%)
		DUF5401	<630..>902	CDD:375164	262/271 (97%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	906..937		30/30 (100%)
		Globular	907..1027		114/124 (92%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C83953619
Domainoid	1	1.000	1319	1.000	Domainoid score	I887
eggNOG	1	0.900	-	-		E2759_KOG0240
HGNC	1	1.500	-	-
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H55861
Inparanoid	1	1.050	1970	1.000	Inparanoid score	I1673
Isobase	0	0.000	Not matched by this tool.
NCBI	1	1.000	-	-
OMA	1	1.010	-	-		QHG52972
OrthoDB	1	1.010	-	-		D1334528at2759
OrthoFinder	1	1.000	-	-		FOG0000669
OrthoInspector	1	1.000	-	-		oto125873
orthoMCL	1	0.900	-	-		OOG6_100344
Panther	1	1.100	-	-	LDO	PTHR24115
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2595
SonicParanoid	1	1.000	-	-		X952
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	18	18.300