DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment KIF5A and kif5a

DIOPT Version :9

Sequence 1:NP_004975.2 Gene:KIF5A / 3798 HGNCID:6323 Length:1032 Species:Homo sapiens
Sequence 2:XP_031751457.1 Gene:kif5a / 100124766 XenbaseID:XB-GENE-983714 Length:1040 Species:Xenopus tropicalis


Alignment Length:1043 Identity:913/1043 - (87%)
Similarity:977/1043 - (93%) Gaps:14/1043 - (1%)


- Green bases have known domain annotations that are detailed below.


Human     1 MAET--NNECSIKVLCRFRPLNQAEILRGDKFIPIFQGDDSVVIGGKPYVFDRVFPPNTTQEQVY 63
            ||:.  |.|||||||||||||||:|:.|||||:|||||.|:|::|||||.|||||||||||||||
 Frog     1 MADNSINTECSIKVLCRFRPLNQSEVQRGDKFLPIFQGGDTVIVGGKPYAFDRVFPPNTTQEQVY 65

Human    64 HACAMQIVKDVLAGYNGTIFAYGQTSSGKTHTMEGKLHDPQLMGIIPRIARDIFNHIYSMDENLE 128
            |||||||||||||||||||||||||:||||||||||||||||||||||||||||||||:||||||
 Frog    66 HACAMQIVKDVLAGYNGTIFAYGQTASGKTHTMEGKLHDPQLMGIIPRIARDIFNHIYAMDENLE 130

Human   129 FHIKVSYFEIYLDKIRDLLDVTKTNLSVHEDKNRVPFVKGCTERFVSSPEEILDVIDEGKSNRHV 193
            |||||||||||||||||||||:|||||||||||||||||||||||||||||||||||||||||||
 Frog   131 FHIKVSYFEIYLDKIRDLLDVSKTNLSVHEDKNRVPFVKGCTERFVSSPEEILDVIDEGKSNRHV 195

Human   194 AVTNMNEHSSRSHSIFLINIKQENMETEQKLSGKLYLVDLAGSEKVSKTGAEGAVLDEAKNINKS 258
            ||||||||||||||||||||||||:||||||||||||||||||||||||||||:|||||||||||
 Frog   196 AVTNMNEHSSRSHSIFLINIKQENIETEQKLSGKLYLVDLAGSEKVSKTGAEGSVLDEAKNINKS 260

Human   259 LSALGNVISALAEGTKSYVPYRDSKMTRILQDSLGGNCRTTMFICCSPSSYNDAETKSTLMFGQR 323
            ||||||||||||||:|.||||||||||||||||||||||||||||||||||||||||||||||||
 Frog   261 LSALGNVISALAEGSKGYVPYRDSKMTRILQDSLGGNCRTTMFICCSPSSYNDAETKSTLMFGQR 325

Human   324 AKTIKNTASVNLELTAEQWKKKYEKEKEKTKAQKETIAKLEAELSRWRNGENVPETERLA-GEEA 387
            |||||||||||||||||||||||||||||.|..||||.|||||||||||||||||||:|: ||: 
 Frog   326 AKTIKNTASVNLELTAEQWKKKYEKEKEKNKTLKETIQKLEAELSRWRNGENVPETEQLSDGEQ- 389

Human   388 ALGAELCEETPVND-NSSIVVRIAPEERQKYEEEIRRLYKQLDDKDDEINQQSQLIEKLKQQMLD 451
             |..:...|||||| |||||:||:.|||:|||||||::|||||||||||||||||:|||||||||
 Frog   390 -LTQDTANETPVNDNNSSIVIRISEEERKKYEEEIRKMYKQLDDKDDEINQQSQLVEKLKQQMLD 453

Human   452 QEELLVSTRGDNEKVQRELSHLQSENDAAKDEVKEVLQALEELAVNYDQKSQEVEEKSQQNQLLV 516
            |:|||:||||||:|||.|||.||||||:||:||||||||||||||||||||||||:|:.||::|.
 Frog   454 QDELLISTRGDNDKVQMELSRLQSENDSAKEEVKEVLQALEELAVNYDQKSQEVEDKTLQNKILA 518

Human   517 DELSQKVATMLSLESELQRLQEVSGHQRKRIAEVLNGLMKDLSEFSVIVGNGEIKLPVEISGAIE 581
            ||||||||.::|||::|.||||.|.||||||||||||||||||||||||||||.|||||||||||
 Frog   519 DELSQKVANLMSLENDLHRLQEFSSHQRKRIAEVLNGLMKDLSEFSVIVGNGEFKLPVEISGAIE 583

Human   582 EEFTVARLYISKIKSEVKSVVKRCRQLENLQVECHRKMEVTGRELSSCQLLISQHEAKIRSLTEY 646
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
 Frog   584 EEFTVARLYISKIKSEVKSVVKRCRQLENLQVECHRKMEVTGRELSSCQLLISQHEAKIRSLTEY 648

Human   647 MQSVELKKRHLEESYDSLSDELAKLQAQETVHEVALKDKEPDTQDADEVKKALELQMESHREAHH 711
            |.|||||||.||||||:||:||||:|.||.|.|||:||||.|..:|.||||.||:||||||||||
 Frog   649 MHSVELKKRQLEESYDALSEELAKMQVQENVTEVAIKDKEQDAMEAYEVKKVLEMQMESHREAHH 713

Human   712 RQLARLRDEINEKQKTIDELKDLNQKLQLELEKLQADYEKLKSEEHEKSTKLQELTFLYERHEQS 776
            :||||||||||||||.||||||||||||||||||:||||||||||||||.||||||||||:||||
 Frog   714 KQLARLRDEINEKQKIIDELKDLNQKLQLELEKLRADYEKLKSEEHEKSHKLQELTFLYEKHEQS 778

Human   777 KQDLKGLEETVARELQTLHNLRKLFVQDVTTRVKKSAEMEPEDSGGIHSQKQKISFLENNLEQLT 841
            ||||||||||||||||||||||||||||||:||||||||||||||||||||||||||||||||||
 Frog   779 KQDLKGLEETVARELQTLHNLRKLFVQDVTSRVKKSAEMEPEDSGGIHSQKQKISFLENNLEQLT 843

Human   842 KVHKQ-------LVRDNADLRCELPKLEKRLRATAERVKALEGALKEAKEGAMKDKRRYQQEVDR 899
            |||||       |||||||||||||||||||||||||||||||||||||||||||||||||||||
 Frog   844 KVHKQLDDWVSKLVRDNADLRCELPKLEKRLRATAERVKALEGALKEAKEGAMKDKRRYQQEVDR 908

Human   900 IKEAVRYKSSGKRGHSAQIAKPVRPGHYPASSPTNPYGTRSPECISYTNSLFQNYQNLYLQATPS 964
            ||||||||::.||.|:||||||:|||||||||||||||.|:.:.|||||:|||||||:|::|| |
 Frog   909 IKEAVRYKNTVKRAHTAQIAKPIRPGHYPASSPTNPYGIRNSDSISYTNNLFQNYQNIYMRAT-S 972

Human   965 STSDMYFANSCTSSGATSSGGPLASYQKANMDNGNATDINDNRSDLPCGYEAEDQAKLFPLHQET 1029
            .:|:.:|||.|:|:..:||.|.|.||||.|:||||||||||||||||||.|||||:|||||||||
 Frog   973 PSSETFFANPCSSTRGSSSSGSLLSYQKMNVDNGNATDINDNRSDLPCGCEAEDQSKLFPLHQET 1037

Human  1030 AAS 1032
            |||
 Frog  1038 AAS 1040

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
KIF5ANP_004975.2 KISc_KHC_KIF5 7..327 CDD:276820 303/319 (95%)
Microtubule-binding 174..315 136/140 (97%)
Necessary for interaction with ZFYVE27. /evidence=ECO:0000250|UniProtKB:P33175 271..361 84/89 (94%)
Interaction with BICD2. /evidence=ECO:0000269|PubMed:20386726 353..1032 578/687 (84%)
Smc <412..759 CDD:224117 301/346 (87%)
DUF5401 <630..>902 CDD:375164 249/278 (90%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 906..939 26/32 (81%)
Globular 907..1032 90/124 (73%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 978..1010 22/31 (71%)
kif5aXP_031751457.1 KISc_KHC_KIF5 9..329 CDD:276820 303/319 (95%)
46 <423..>510 CDD:222878 76/86 (88%)
Smc <581..911 CDD:224117 300/329 (91%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 1166 1.000 Domainoid score I437
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 1 1.000 - - H55861
Inparanoid 1 1.050 1790 1.000 Inparanoid score I920
NCBI 1 1.000 - -
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D1334528at2759
OrthoFinder 1 1.000 - - FOG0000669
OrthoInspector 1 1.000 - - otm55168
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X952
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
99.060

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