DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment NKAIN and NKAIN1

DIOPT Version :9

Sequence 1:	NP_001246506.1	Gene:	NKAIN / 37979	FlyBaseID:	FBgn0085442	Length:	658	Species:	Drosophila melanogaster
Sequence 2:	NP_078798.2	Gene:	NKAIN1 / 79570	HGNCID:	25743	Length:	207	Species:	Homo sapiens

Alignment Length:	214	Identity:	96/214 - (44%)
Similarity:	130/214 - (60%)	Gaps:	23/214 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MGSCS--CTRRHFLLSICFLQVITIIERQVFDFLGYMWAPILVNFFHILFIIFGFYGAYHFRVKY 63
            ||.||  ||    |::.|.||::..:|||:||||||.|||||.||.||:.:|.|.:|...:|.:|
Human     1 MGKCSGRCT----LVAFCCLQLVAALERQIFDFLGYQWAPILANFLHIMAVILGIFGTVQYRSRY 61

  Fly    64 IITYLIWNFLWIGWNTFLICFYLNVGQLNRDSDLLNLGTGSV--SWFEANGYGC--KPTYN--MA 122
            :|.|..|..||:|||.|:|||||.||||::|.|.:.....|:  ||:..||.||  .|..|  :|
Human    62 LILYAAWLVLWVGWNAFIICFYLEVGQLSQDRDFIMTFNTSLHRSWWMENGPGCLVTPVLNSRLA 126

  Fly   123 ADDTFRPQRPERVEGCLLDYPLVEITHSGVQCALALLGILGAILISCIFLDEDDRFDFMNG-DA- 185
            .:|    .....|.|||||||.:|...|.:|..|||.|.:.|..:|.:||:|:|.|||:.| |:
Human   127 LED----HHVISVTGCLLDYPYIEALSSALQIFLALFGFVFACYVSKVFLEEEDSFDFIGGFDSY 187

  Fly   186 --KSPQ---HTVVHPMYVS 199
              ::||   |..:.|:|.|
Human   188 GYQAPQKTSHLQLQPLYTS 206

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
NKAIN	NP_001246506.1	NKAIN	12..199	CDD:283329	89/199 (45%)
NKAIN1	NP_078798.2	NKAIN	10..206	CDD:398973	89/199 (45%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165141035
Domainoid	1	1.000	178	1.000	Domainoid score	I3564
eggNOG	1	0.900	-	-		E1_KOG4556
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001076
OrthoInspector	1	1.000	-	-		otm41902
orthoMCL	1	0.900	-	-		OOG6_106588
Panther	1	1.100	-	-	O	PTHR13084
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X730
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	10	9.700