Protein Alignment Atf-2 and CREB5

DIOPT Version :10

• Sequence 1: NP_001033973.1
• Gene: Atf-2 / 37978
• FlyBaseID: FBgn0265193
• Length: 381
• Species: Drosophila melanogaster
• Sequence 2: XP_054215370.1
• Gene: CREB5 / 9586
• HGNCID: 16844
• Length: 551
• Species: Homo sapiens
• Alignment Length: 445
• Identity: 101/445 - (22%)
• Similarity: 151/445 - (33%)
• Gaps: 174/445 - (39%)

  Fly    29 CYQNFRAQTEHVSL-----DISL---GQKSDTLFAADQTPTPTRLIKNCDEVGLFED----LQHV 81
            |.|.|..: :|:.:     :::|   ..|:|.:. :||||||||.:|||:|||||.:    |:|
Human    66 CSQRFPTE-DHLMIHRHKHEMTLKFPSIKTDNML-SDQTPTPTRFLKNCEEVGLFSELDCSLEH- 127

  Fly    82 NPFDIGFQQAAE-----RNVS------------GTPSRPEAR-PNDGESLHTPQVY--PVEAPTV 126
                 .|::|.|     ||:|            ||.....|| ||...::...|..  |..:..:
Human   128 -----EFRKAQEEESSKRNISMHNAVGGAMTGPGTHQLSSARLPNHDTNVVIQQAMPSPQSSSVI 187

  Fly   127 VSVPSENQ----VPQSVSCGDMDVDQL--LATTVTSPSKASQDG--PPPLQLIQPQVLTWVLPAQ 183
            ...||.|:    ||.|:|       .|  |......|..||..|  |.|.......||..:....
Human   188 TQAPSTNRQIGPVPGSLS-------SLLHLHNRQRQPMPASMPGTLPNPTMPGSSAVLMPMERQM 245

  Fly   184 SVPISIATVD-------CNRNRVKPT--------------------------------------- 202
            ||..||..:.       |...:|:|.
Human   246 SVNSSIMGMQGPNLSNPCASPQVQPMHSEAKMRLKAALTHHPAAMSNGNMNTMGHMMEMMGSRQD 310

  Fly   203 -----------------------------GAIHPFILPKPTAKE----------------LNKTS 222
                                         .|.||.  |:|..::                .::||
Human   311 QTPHHHMHSHPHQHQTLPPHHPYPHQHQHPAHHPH--PQPHHQQNHPHHHSHSHLHAHPAHHQTS 373

  Fly   223 KRPEPILVSCNPPNNEPSSASLTPTSQL----PIKERLKAIIHS--NNNRRSFSTPPKAAKAKDR 281
              |.|.|.:.|.....|::..:.||..:    |...|.:.::..  :..||.|
Human   374 --PHPPLHTGNQAQVSPATQQMQPTQTIQPPQPTGGRRRRVVDEDPDERRRKF------------ 424

  Fly   282 SRDEDCMERRRAAASRYRNKMRNEHKDLIKQNAQLQQENQELHERISRLEKELQQ 336
                  :||.||||:|.|.|.:.....|.|:..:|.|.|.:|...:|.|:.|:.|
Human   425 ------LERNRAAATRCRQKRKVWVMSLEKKAEELTQTNMQLQNEVSMLKNEVAQ 473

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Atf-2	NP_001033973.1	Jnk-SapK_ap_N	<302..343	CDD:462875	10/35 (29%)
CREB5	XP_054215370.1	bZIP_ATF2	420..479	CDD:269835	22/72 (31%)
		coiled coil	420..479	CDD:269835	22/72 (31%)