DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Atf-2 and Fosl2

DIOPT Version :9

Sequence 1:NP_001033973.1 Gene:Atf-2 / 37978 FlyBaseID:FBgn0265193 Length:381 Species:Drosophila melanogaster
Sequence 2:NP_032063.2 Gene:Fosl2 / 14284 MGIID:102858 Length:326 Species:Mus musculus


Alignment Length:291 Identity:62/291 - (21%)
Similarity:106/291 - (36%) Gaps:94/291 - (32%)


- Green bases have known domain annotations that are detailed below.


  Fly    74 LFEDLQHVNPFDIGFQQAAERNVSGTPSRPEARPNDGESLHTPQVYPVEAPTVVS--VPSENQVP 136
            :::|  :...||     .:.|..||:|:..|:..:.|..   .|.:.|:.|...|  :|:.|.: 
Mouse     1 MYQD--YPGNFD-----TSSRGSSGSPAHAESYSSGGGG---QQKFRVDMPGSGSAFIPTINAI- 54

  Fly   137 QSVSCGDMDVDQLLATTVTSPSKASQDGPPPLQ-LIQPQVLTWVLPAQSVPISIATVDCNRNRVK 200
                           ||       |||    || ::||.|:|                   :...
Mouse    55 ---------------TT-------SQD----LQWMVQPTVIT-------------------SMSN 74

  Fly   201 PTGAIHPFILPKPTAKELNKTSKRPEPILVSCNPPNNEPSSASLTPTSQLPIKERLKAIIHSNNN 265
            |....||:                 .|:          |..||:.....||....:|.|..:...
Mouse    75 PYPRSHPY-----------------SPL----------PGLASVPGHMALPRPGVIKTIGTTVGR 112

  Fly   266 RRSFSTPPKAAKAKDRSRDEDCMERRRAAASRYRNKMRNEHKDLIKQNAQLQQENQELHERISRL 330
            ||.........:.|.|.|    .||.:.||::.||:.|...:.|..:..:|::|...|.:.|:.|
Mouse   113 RRRDEQLSPEEEEKRRIR----RERNKLAAAKCRNRRRELTEKLQAETEELEEEKSGLQKEIAEL 173

  Fly   331 EKELQQHR----SHSSLAGVVADQLRIPPSS 357
            :||.::..    :|..:..:..::.|.||:|
Mouse   174 QKEKEKLEFMLVAHGPVCKISPEERRSPPTS 204

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Atf-2NP_001033973.1 Cnn_1N <300..336 CDD:285263 10/35 (29%)
Fosl2NP_032063.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..39 10/47 (21%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 110..131 5/24 (21%)
Basic motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU00978 126..128 1/1 (100%)
Leucine-zipper. /evidence=ECO:0000255|PROSITE-ProRule:PRU00978 129..136 3/10 (30%)
bZIP_Fos 134..187 CDD:269869 13/52 (25%)
coiled coil 134..186 CDD:269869 13/51 (25%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 193..244 4/12 (33%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 285..326
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R103
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
11.030

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