DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Atf-2 and Fos

DIOPT Version :9

Sequence 1:	NP_001033973.1	Gene:	Atf-2 / 37978	FlyBaseID:	FBgn0265193	Length:	381	Species:	Drosophila melanogaster
Sequence 2:	NP_034364.1	Gene:	Fos / 14281	MGIID:	95574	Length:	380	Species:	Mus musculus

Alignment Length:	305	Identity:	73/305 - (23%)
Similarity:	108/305 - (35%)	Gaps:	91/305 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    84 FDIGFQQAAERNVSGTPSRPEARPNDGESL---HTPQVYPVEAPTVVSVPSENQVPQSVSCGDMD 145
            |:..::.::.|..|.:|:        |:||   |:|      |.:..|:.|  .|.....|.|:.
Mouse     6 FNADYEASSSRCSSASPA--------GDSLSYYHSP------ADSFSSMGS--PVNTQDFCADLS 54

  Fly   146 VDQL-LATTVTSPSKASQDGPPPLQ-LIQPQVLTWVLPAQSVPISIATVDCNRNRVKPTGAIHPF 208
            |... ...|||:.|.:     |.|| |:||.:::.|.|:|                  |.|.||:
Mouse    55 VSSANFIPTVTAISTS-----PDLQWLVQPTLVSSVAPSQ------------------TRAPHPY 96

  Fly   209 ILPKPTAKELNKTSKRPEPILVSCNPPNNEPSSASLTPTSQLPIKERLKAIIHSNNNRRSFSTPP 273
            .||..:|....:..      :|.........|........||..:|..|..|     ||
Mouse    97 GLPTQSAGAYARAG------MVKTVSGGRAQSIGRRGKVEQLSPEEEEKRRI-----RR------ 144

  Fly   274 KAAKAKDRSRDEDCMERRRAAASRYRNKMRNEHKDLIKQNAQLQQENQELHERISRLEKE----- 333
                           ||.:.||::.||:.|.....|..:..||:.|...|...|:.|.||
Mouse   145 ---------------ERNKMAAAKCRNRRRELTDTLQAETDQLEDEKSALQTEIANLLKEKEKLE 194

  Fly   334 --LQQHRSHSSLAGVVADQLRIPP----SSIHLLINVPNVLVPSS 372
              |..||.    |..:.|.|..|.    :|:.|...:|....|.|
Mouse   195 FILAAHRP----ACKIPDDLGFPEEMSVASLDLTGGLPEASTPES 235

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Atf-2	NP_001033973.1	Cnn_1N	<300..336	CDD:285263	12/42 (29%)
Fos	NP_034364.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	117..141		5/23 (22%)
		Basic motif, required for the activation of phospholipid synthesis, but not for CDS1-binding	139..159		10/45 (22%)
		bZIP_Fos	147..200	CDD:269869	15/52 (29%)
		coiled coil	147..199	CDD:269869	15/51 (29%)
		Leucine-zipper. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00978	165..193		9/27 (33%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	354..380
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R103
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.030