DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG16896 and TBC1D31

DIOPT Version :10

Sequence 1:NP_611973.2 Gene:CG16896 / 37977 FlyBaseID:FBgn0035073 Length:988 Species:Drosophila melanogaster
Sequence 2:NP_663622.2 Gene:TBC1D31 / 93594 HGNCID:30888 Length:1066 Species:Homo sapiens


Alignment Length:976 Identity:256/976 - (26%)
Similarity:407/976 - (41%) Gaps:237/976 - (24%)


- Green bases have known domain annotations that are detailed below.


  Fly    99 VHHTIKEAGQALRIQIAACCFNELSNKLVVIDKRGNVFVFDFVRKRYWRLGFRMPKAKLIRPSPL 163
            :|:|.....:.||....|  |:...:.|:..|.:||::|||                       |
Human    32 IHNTSDYHPKVLRFLNVA--FDGTGDCLIAGDHQGNIYVFD-----------------------L 71

  Fly   164 HGSDYIVGNKTGHIFT--------------IDVDNSILGVDGEVGSAALEELSWSNSLQNARSSI 214
            ||:.:.:..:|....|              ...|.||...|    :...|.:||....:::..||
Human    72 HGNRFNLVQRTAQACTALAFNLRRKSEFLVALADYSIKCFD----TVTKELVSWMRGHESSVFSI 132

  Fly   215 ALMRFGSDAL--------LVNLHTLEVSHQLDFDQSRYTLKFAAFLPHSDQFFIGFSNDSLHVWS 271
            ::...|..|:        |.:|.|.:...:|:..|| ..::...|||.|:.....|.::|:..|.
Human   133 SVHASGKYAITTSSDTAQLWDLDTFQRKRKLNIRQS-VGIQKVFFLPLSNTILSCFKDNSIFAWE 196

  Fly   272 SHSL-STLRMGQP---------IKARNRKLRLLPA-------------AESIPEIV-----LRS- 307
            ..:| ...::..|         :.|..|..|:|.|             |..:..|:     :|: 
Human   197 CDTLFCKYQLPAPPESSSILYKVFAVTRDGRILAAGGKSNHLHLWCLEARQLFRIIQMPTKVRAI 261

  Fly   308 ------PDDSD---------LEED------------LTFDCQHYDFADGMLLSYCFTPDGNKMCL 345
                  ||..|         |.:|            |.|:....|  :| :.|...:|.|..:..
Human   262 RHLEFLPDSFDAGSNQVLGVLSQDGIMRFINMQTCKLLFEIGSLD--EG-ISSSAISPHGRYIAS 323

  Fly   346 STLDGYLLLLSVASFDLEKMYRLTDFTLHQMAFLSQPKERIVFGI--TTRNQAVMLDLANTDHKL 408
            ...:|.|.:.||.:...|               :::|...:|..|  ..:|:     |:::|.|:
Human   324 IMENGSLNIYSVQALTQE---------------INKPPPPLVKVIEDLPKNK-----LSSSDLKM 368

  Fly   409 IVQRSNARSLSLSRDGKLLSVTSRCGEVNVWSTCRIFNALQAQIRCLSQ-VKSTFKQPNPLPPCS 472
            .|.....:..:.||:.|:                        |.|.|.| :...|:..       
Human   369 KVTSGRVQQPAKSRESKM------------------------QTRILKQDLTGDFESK------- 402

  Fly   473 VGGGVSKELRDLLNPQRLKTMLKEYGCYPEKYRYLIWTSLLDLPCNGPQFQELIKLGAPLLVRNR 537
                 ..||.|.||.:||:.:||.||.||.|||..||.|||.||.|...|..||..|..:...|.
Human   403 -----KNELPDGLNKKRLQILLKGYGEYPTKYRMFIWRSLLQLPENHTAFSTLIDKGTHVAFLNL 462

  Fly   538 AKKLKIRNDHQRRVVIKIWSCLAQWCKVLAHADFMPHLIFPFVKRMPKNSLVCFELIATLVLNHF 602
            .||..|::....||:.:..|.||.|..:.:...::|.|.|||||....|.|:|||:||||::|..
Human   463 QKKYPIKSRKLLRVLQRTLSALAHWSVIFSDTPYLPLLAFPFVKLFQNNQLICFEVIATLIINWC 527

  Fly   603 QLCFEFHPLPPSNYLAMCENILQHCDEQLCKFYKSQEMLPKDFAWPLLSTAFSEVLEEEQWLSLW 667
            |..||:.|.||.|.|:|.||:|...|::|.:.:...::..:.:|||||.|.|||||..|:||.|:
Human   528 QHWFEYFPNPPINILSMIENVLAFHDKELLQHFIDHDITSQLYAWPLLETVFSEVLTREEWLKLF 592

  Fly   668 DNIFSEPPWFPVFLVVAYNLINREIILRLPDKRSVLFFFHDQNPVDISKLLSKARKLMSKCALAL 732
            |||||..|.|.:..|||||:.:|..:|....|....||||.:|.:||:.::.:...||......:
Human   593 DNIFSNHPSFLLMTVVAYNICSRTPLLSCNLKDDFEFFFHHRNNLDINVVIRQVYHLMETTPTDI 657

  Fly   733 HPQRFMTHFSPIPKGVYPKFLKYPSEWIDEQEYQAVSLIKHNQEIDARIRHLELEEVKIMERLET 797
            ||...:..|..:.||.||.|.:||...:|.|..:...:  .|.|:|      .|.|.:.:|.::.
Human   658 HPDSMLNVFVALTKGQYPVFNQYPKFIVDYQTQERERI--RNDELD------YLRERQTVEDMQA 714

  Fly   798 GLKQEEHARRLKEMERVYQDTIHREEERITCQRKMLLTYQMEVRRRKSEVITKLQESE----QRR 858
            .:.|:                  |.|:....|::.||....|.||   |::  |||.|    ||:
Human   715 KVDQQ------------------RVEDEAWYQKQELLRKAEETRR---EML--LQEEEKMIQQRQ 756

  Fly   859 KILEMEKDMDLL-MHSIERERRRHNQEMQLAEDEIRNQEMELLAQRYYSDTEGAPLAQKYYDKIQ 922
            ::..:::::.:. ||..:..|||.   ::|.:|:   |||||               ::..|:|.
Human   757 RLAAVKRELKVKEMHLQDAARRRF---LKLQQDQ---QEMEL---------------RRLDDEIG 800

  Fly   923 KLCYQRD-QLQKNLRDMTMEQLRTPATSSVQFSPQLVDIENSIFEIQREFTEIITTDKTLEYRRN 986
            :..|.|| ::....||:.|.||...:...:        .|.::.|.|....:.:..|.. .|||.
Human   801 RKVYMRDREIAATARDLEMRQLELESQKRL--------YEKNLTENQEALAKEMRADAD-AYRRK 856

  Fly   987 L 987
            :
Human   857 V 857

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG16896NP_611973.2 DUF5401 <754..>987 CDD:375164 55/238 (23%)
TBC1D31NP_663622.2 WD 1 33..74 15/65 (23%)
WD40 44..340 CDD:441893 65/328 (20%)
WD40 repeat 46..81 CDD:293791 12/59 (20%)
WD 2 75..116 6/44 (14%)
WD40 repeat 86..123 CDD:293791 8/40 (20%)
WD 3 117..157 9/39 (23%)
WD40 repeat 130..164 CDD:293791 7/33 (21%)
WD 4 158..200 10/42 (24%)
WD40 repeat 171..207 CDD:293791 8/35 (23%)
WD 5 201..248 7/46 (15%)
WD40 repeat 215..253 CDD:293791 7/37 (19%)
WD 6 249..296 7/46 (15%)
WD40 repeat 261..291 CDD:293791 5/29 (17%)
WD 7 297..334 9/39 (23%)
WD40 repeat 309..335 CDD:293791 5/25 (20%)
RabGAP-TBC 462..605 CDD:480642 62/142 (44%)
DUF5401 <684..>962 CDD:375164 53/235 (23%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 989..1020
Mediates direct interaction with PJA2. /evidence=ECO:0000269|PubMed:33934390 1053..1056
Blue background indicates that the domain is not in the aligned region.

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