Protein Alignment Dll and NKX6-2

DIOPT Version :9

• Sequence 1: NP_001137759.1
• Gene: Dll / 37973
• FlyBaseID: FBgn0000157
• Length: 347
• Species: Drosophila melanogaster
• Sequence 2: NP_796374.2
• Gene: NKX6-2 / 84504
• HGNCID: 19321
• Length: 277
• Species: Homo sapiens
• Alignment Length: 225
• Identity: 71/225 - (31%)
• Similarity: 103/225 - (45%)
• Gaps: 41/225 - (18%)

  Fly    41 AAAG--YGGI-------RSTYQHFGPQGGQDSGFPSPRSAL-GYP---FPPMHQNSYSGYHLGSY 92
            ||.|  .||:       .|...:|||......|:|.|.:.| |.|   :|.:.|.:       .:
Human    70 AAGGGLLGGLPRLNGLASSAGVYFGPAAAVARGYPKPLAELPGRPPIFWPGVVQGA-------PW 127

  Fly    93 APPCASPPKDDFSISDKCEDSGLRVNGKGKKMRKPRTIYSSLQLQQLNRRFQRTQYLALPERAEL 157
            ..|..:.|.....:.||          .||| :..|..:|..|:..|.:.|::|:|||.||||.|
Human   128 RDPRLAGPAPAGGVLDK----------DGKK-KHSRPTFSGQQIFALEKTFEQTKYLAGPERARL 181

  Fly   158 AASLGLTQTQVKIWFQNRRSKYKKM----MKAAQGPGTNSGMPLGGGGPNPGQ----HSPNQMHS 214
            |.|||:|::|||:||||||:|::|.    |.:|:....:....|..||.:...    :.|...:|
Human   182 AYSLGMTESQVKVWFQNRRTKWRKRHAVEMASAKKKQDSDAEKLKVGGSDAEDDDEYNRPLDPNS 246

  Fly   215 GELANGRFLWAALETNGTLALVHSTGGNNG 244
            .:....|.|.....:|  ||||...||..|
Human   247 DDEKITRLLKKHKPSN--LALVSPCGGGAG 274

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Dll	NP_001137759.1	Homeobox	127..180	CDD:278475	29/52 (56%)
NKX6-2	NP_796374.2	Repressor domain. /evidence=ECO:0000250|UniProtKB:D3Z4R4	89..142		13/59 (22%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	132..155		7/33 (21%)
		Homeobox	151..204	CDD:306543	29/52 (56%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	210..250		7/39 (18%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0850
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.810