Protein Alignment Dll and ALX1

DIOPT Version :10

• Sequence 1: NP_001137759.1
• Gene: Dll / 37973
• FlyBaseID: FBgn0000157
• Length: 347
• Species: Drosophila melanogaster
• Sequence 2: NP_008913.2
• Gene: ALX1 / 8092
• HGNCID: 1494
• Length: 326
• Species: Homo sapiens
• Alignment Length: 306
• Identity: 74/306 - (24%)
• Similarity: 112/306 - (36%)
• Gaps: 93/306 - (30%)

  Fly     1 MDAPDAPHTPKYMDGGNTAASVTPGINIPGKSAFVELQQHAAAGYGGIRSTYQHFGPQGGQDSGF 65
            :.:|.:.::..||..|.....|...::   ..:|   ...|:||     ...|.|||....:...
Human    10 LKSPPSKNSDFYMGAGGPLEHVMETLD---NESF---YSKASAG-----KCVQAFGPLPRAEHHV 63

  Fly    66 ------PSPRSALGYPF-----PPMHQNSYSGYHLGSYAPPC----ASPPK--------DDFSIS 107
                  |...|::.|..     .|:|.      .|......|    .||.|        |:  :.
Human    64 RLERTSPCQDSSVNYGITKVEGQPLHT------ELNRAMDNCNSLRMSPVKGMQEKGELDE--LG 120

  Fly   108 DKCEDSGLRVNGKGKKMRKPRTIYSSLQLQQLNRRFQRTQYLALPERAELAASLGLTQTQVKIWF 172
            |||:.     |....|.|:.||.::||||::|.:.||:|.|..:..|.:||....||:.:|::||
Human   121 DKCDS-----NVSSSKKRRHRTTFTSLQLEELEKVFQKTHYPDVYVREQLALRTELTEARVQVWF 180

  Fly   173 QNRRSKYKKMMKAAQGPGTNSG---------MPLGGGGPNPGQHSPNQMHSGELANGRFLWAALE 228
            ||||:|::|..:..|.....|.         :|.....|             ::.|.  |||
Human   181 QNRRAKWRKRERYGQIQQAKSHFAATYDISVLPRTDSYP-------------QIQNN--LWA--- 227

  Fly   229 TNGTLALVHSTGGNNGGGS-------NSGSPSHYLPPGHSPTPSST 267
                        ||..|||       ...:.|...|..|||...|:
Human   228 ------------GNASGGSVVTSCMLPRDTSSCMTPYSHSPRTDSS 261

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Dll	NP_001137759.1	Homeodomain	125..181	CDD:459649	25/55 (45%)
ALX1	NP_008913.2	Homeodomain	133..189	CDD:459649	25/55 (45%)
		Transactivation domain. /evidence=ECO:0000250|UniProtKB:Q63087	192..326		19/100 (19%)
		OAR	302..320	CDD:461067
		OAR. /evidence=ECO:0000255|PROSITE-ProRule:PRU00138	306..319