Protein Alignment Dll and NKX2-1

DIOPT Version :10

• Sequence 1: NP_001137759.1
• Gene: Dll / 37973
• FlyBaseID: FBgn0000157
• Length: 347
• Species: Drosophila melanogaster
• Sequence 2: NP_001073136.1
• Gene: NKX2-1 / 7080
• HGNCID: 11825
• Length: 401
• Species: Homo sapiens
• Alignment Length: 343
• Identity: 99/343 - (28%)
• Similarity: 131/343 - (38%)
• Gaps: 106/343 - (30%)

  Fly    13 MDGGNTAASVT---PGINIPGKSAFVELQQHAAAGYGGIRSTYQHFG---PQ------GGQDSGF 65
            |:||...|.:.   .|...|..:|   :||||...:|.:.:.|....   ||      ||..:|.
Human    59 MEGGGLGAPLAAYRQGQAAPPTAA---MQQHAVGHHGAVTAAYHMTAAGVPQLSHSAVGGYCNGN 120

  Fly    66 PSPRSALGYPFPPMHQNSYSGYHLGSYAPPCASPPKDDFSISD-KCEDSGLRVNGKG-------- 121
            ....|.|. |:....:||.||  .|.|.   |:|.....:||. ....||:.::|.|
Human   121 LGNMSELP-PYQDTMRNSASG--PGWYG---ANPDPRFPAISRFMGPASGMNMSGMGGLGSLGDV 179

  Fly   122 -KKM--------RKPRTIYSSLQLQQLNRRFQRTQYLALPERAELAASLGLTQTQVKIWFQNRRS 177
             |.|        ||.|.::|..|:.:|.|||::.:||:.|||..||:.:.||.|||||||||.|.
Human   180 SKNMAPLPSAPRRKRRVLFSQAQVYELERRFKQQKYLSAPEREHLASMIHLTPTQVKIWFQNHRY 244

  Fly   178 KYKKMM--KAAQ------------GPGT----------------------NSGMPLGGGGPNPGQ 206
            |.|:..  ||||            |.||                      ..|.|...|.|.||.
Human   245 KMKRQAKDKAAQQQLQQDSGGGGGGGGTGCPQQQQAQQQSPRRVAVPVLVKDGKPCQAGAPAPGA 309

  Fly   207 -----HSPNQ-MHSGELANGRFLWAALETNGTLALVHSTGGNNGGGSNSGSPSHYLPPGHSPTPS 265
                 |:..| .|..:.|.            ..|...|.|   .||:..|  :|   |||.|..:
Human   310 ASLQGHAQQQAQHQAQAAQ------------AAAAAISVG---SGGAGLG--AH---PGHQPGSA 354

  Fly   266 STPVSELSPEFPPTGLSP 283
            ..     ||:......||
Human   355 GQ-----SPDLAHHAASP 367

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Dll	NP_001137759.1	Homeodomain	125..181	CDD:459649	29/55 (53%)
NKX2-1	NP_001073136.1	Homeodomain	192..248	CDD:459649	29/55 (53%)