DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Dll and Nkx6-1

DIOPT Version :9

Sequence 1:	NP_001137759.1	Gene:	Dll / 37973	FlyBaseID:	FBgn0000157	Length:	347	Species:	Drosophila melanogaster
Sequence 2:	NP_113925.1	Gene:	Nkx6-1 / 65193	RGDID:	69318	Length:	365	Species:	Rattus norvegicus

Alignment Length:	199	Identity:	57/199 - (28%)
Similarity:	89/199 - (44%)	Gaps:	23/199 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 DAPDAPHTPKYMDGGNTAASVTPGINIPGKSAFVELQQHAAAGYGGIRSTYQHFGPQGGQDSGFP 66
            |....|..|  :..|....|.:|..:....|:.......:||......:.........|..:|.|
  Rat   100 DILSRPSMP--VASGAALPSASPSGSSSSSSSSASATSASAAAAAAAAAAAAAASSPAGLLAGLP 162

  Fly    67 SPRSALGYPFPP----MHQNSYSGYHLGSYAPPCA---------------SPPKDDFSISDKCED 112
            . .|:|..|.||    ...::.:...:|.|..|.|               |||..|..::.....
  Rat   163 R-FSSLSPPPPPPGLYFSPSAAAVAAVGRYPKPLAELPGRTPIFWPGVMQSPPWRDARLACTPHQ 226

  Fly   113 SGLRVNGKGKKMRKPRTIYSSLQLQQLNRRFQRTQYLALPERAELAASLGLTQTQVKIWFQNRRS 177
            ..:.::..||: :..|..:|..|:..|.:.|::|:|||.||||.||.|||:|::|||:||||||:
  Rat   227 GSILLDKDGKR-KHTRPTFSGQQIFALEKTFEQTKYLAGPERARLAYSLGMTESQVKVWFQNRRT 290

  Fly   178 KYKK 181
            |::|
  Rat   291 KWRK 294

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dll	NP_001137759.1	Homeobox	127..180	CDD:278475	29/52 (56%)
Nkx6-1	NP_113925.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	35..136		7/37 (19%)
		Repressor domain. /evidence=ECO:0000250	102..269		38/170 (22%)
		Homeobox	240..294	CDD:395001	29/53 (55%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	295..365		57/199 (29%)
		Involved in DNA-binding. /evidence=ECO:0000250	307..365
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0850
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810