Protein Alignment Dll and NKX2-4

DIOPT Version :10

• Sequence 1: NP_001137759.1
• Gene: Dll / 37973
• FlyBaseID: FBgn0000157
• Length: 347
• Species: Drosophila melanogaster
• Sequence 2: NP_149416.1
• Gene: NKX2-4 / 644524
• HGNCID: 7837
• Length: 354
• Species: Homo sapiens
• Alignment Length: 358
• Identity: 92/358 - (25%)
• Similarity: 122/358 - (34%)
• Gaps: 144/358 - (40%)

  Fly    13 MDGGNTAASVTPGINI----------PGKSAFVELQQHAAAG---YGGIRS-----TYQHFGPQG 59
            |.|.|.||:.......          ||.|.|    .|.|.|   .||:.:     .|.. |.:|
Human    71 MAGHNAAAAAAAAAAAAAAAATYHMPPGVSQF----PHGAMGSYCNGGLGNMGELPAYTD-GMRG 130

  Fly    60 GQDSGF----PSPR-SALGYPFPPMHQNSYSGYHLGS--------------YAPPCASPPKDDFS 105
            |..:|:    |.|| |::.....|....:.:|  :||              :|...|:.|:
Human   131 GAATGWYGANPDPRYSSISRFMGPSAGVNVAG--MGSLTGIADAAKSLGPLHAAAAAAAPR---- 189

  Fly   106 ISDKCEDSGLRVNGKGKKMRKPRTIYSSLQLQQLNRRFQRTQYLALPERAELAASLGLTQTQVKI 170
                               ||.|.::|..|:.:|.|||::.:||:.|||..||:.:.||.|||||
Human   190 -------------------RKRRVLFSQAQVYELERRFKQQKYLSAPEREHLASMIHLTPTQVKI 235

  Fly   171 WFQNRRSKYKKMM--KAAQGPGTNSGMPLGGGGPNPGQHSPNQMHSGELANGRFLWAALETNGTL 233
            ||||.|.|.|:..  ||||     .....||.||.|
Human   236 WFQNHRYKMKRQAKDKAAQ-----QLQQEGGLGPPP----------------------------- 266

  Fly   234 ALVHSTGGNNGGGSNSGSPSHYLPPGHSPTPSSTPVSELSPEFPPTGLSPPTQAPWDQKPHWIDH 298
                                   ||..||...:.||.....:....|.|.||
Human   267 -----------------------PPPPSPRRVAVPVLVKDGKPCQNGASTPT------------- 295

  Fly   299 KPPPQMTPQPPHPAATLHPQTHHHNP-PPQMGG 330
              |.|..||||.|  |..|:....:| ||.:.|
Human   296 --PGQAGPQPPAP--TPAPELEELSPSPPALHG 324

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Dll	NP_001137759.1	Homeodomain	125..181	CDD:459649	29/55 (53%)
NKX2-4	NP_149416.1	Homeodomain	190..246	CDD:459649	29/55 (53%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	246..329		32/153 (21%)