Protein Alignment Dll and DRGX

DIOPT Version :10

• Sequence 1: NP_001137759.1
• Gene: Dll / 37973
• FlyBaseID: FBgn0000157
• Length: 347
• Species: Drosophila melanogaster
• Sequence 2: XP_011538391.1
• Gene: DRGX / 644168
• HGNCID: 21536
• Length: 298
• Species: Homo sapiens
• Alignment Length: 275
• Identity: 63/275 - (22%)
• Similarity: 91/275 - (33%)
• Gaps: 102/275 - (37%)

  Fly   111 EDSGLRVNGKGKKMRKPRTIYSSLQLQQLNRRFQRTQYLALPERAELAASLGLTQTQV------- 168
            :|..||     :|.|:.||.::..||:.|...|.:|.|..:..|.|||..:.||:.:|
Human    25 DDGFLR-----RKQRRNRTTFTLQQLEALEAVFAQTHYPDVFTREELAMKINLTEARVQLANSCL 84

  Fly   169 ----------------------------KIWFQNRRSKYKKMMKAA--QGPGTNSGM------PL 197
                                        ::||||||:|::|..:.|  |.||....|      |:
Human    85 KTELQIEINDTIIEHSEVEDHNFSLKGARVWFQNRRAKWRKTERGASDQEPGAKEPMAEVTPPPV 149

  Fly   198 GG-GGPNPGQHSPNQMHSGELAN---------GRFLWAALETNGTL--------ALVHSTGGNNG 244
            .. ..|.||..:.::..:.|...         |.|..:.|.  |||        ||.|......|
Human   150 RNINSPPPGDQARSKKEALEAQQSLGRTVGPAGPFFPSCLP--GTLLNTATYAQALSHVASLKGG 212

  Fly   245 GGSNSGSPS----HYLPP-------------------GHS----------PTPSSTPVSELSPEF 276
            ...:...|.    .:||.                   .||          |:.||:|.....|.
Human   213 PLCSCCVPDPMGLSFLPTYGCQSNRTASVATLRMKAREHSEAVLQSANLLPSTSSSPGPVAKPA- 276

  Fly   277 PPTGLSPPTQAPWDQ 291
            ||.|....|....:|
Human   277 PPDGSQEKTSPTKEQ 291

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Dll	NP_001137759.1	Homeodomain	125..181	CDD:459649	23/90 (26%)
DRGX	XP_011538391.1	Homeodomain	34..125	CDD:459649	23/90 (26%)
		OAR	236..253	CDD:461067	1/16 (6%)