Protein Alignment Dll and BARHL1

DIOPT Version :10

• Sequence 1: NP_001137759.1
• Gene: Dll / 37973
• FlyBaseID: FBgn0000157
• Length: 347
• Species: Drosophila melanogaster
• Sequence 2: NP_064448.1
• Gene: BARHL1 / 56751
• HGNCID: 953
• Length: 327
• Species: Homo sapiens
• Alignment Length: 270
• Identity: 78/270 - (28%)
• Similarity: 103/270 - (38%)
• Gaps: 93/270 - (34%)

  Fly    67 SPRSALGYPFPPMHQNSYSGYHLGSYAPPCASPPKD--DFSISDKCEDSGLRVNGKG-------- 121
            :|.|:.|.|..|...        |..|...|...:|  |.|.|:...||..:|..:|
Human   112 APYSSSGQPAAPEPG--------GRLAAKAAEDFRDKLDKSGSNASSDSEYKVKEEGDREISSSR 168

  Fly   122 -------KKMRKPRTIYSSLQLQQLNRRFQRTQYLALPERAELAASLGLTQTQVKIWFQNRRSKY 179
                   ||.||.||.::..||.||.|.|:|.:||::.:|.||||||.||.||||.|:||||:|:
Human   169 DSPPVRLKKPRKARTAFTDHQLAQLERSFERQKYLSVQDRMELAASLNLTDTQVKTWYQNRRTKW 233

  Fly   180 KKMMKAAQGPGTNSGMPLGGGGPNPGQHSPNQMHSGELANGRFLWAALETNGTLALVHSTGGNNG 244
            |:.        |..|:.|                ..|..|    ::||:..
Human   234 KRQ--------TAVGLEL----------------LAEAGN----YSALQRM-------------- 256

  Fly   245 GGSNSGSPSHYLPPGHSPTPSSTPVSEL----SPEFPPTGLSPPTQAPWDQKPHWIDH------K 299
                  .||.|..| .|...:..|.:.|    .|..||..|..|.      .|..:.|      :
Human   257 ------FPSPYFYP-QSLVSNLDPGAALYLYRGPSAPPPALQRPL------VPRILIHGLQGASE 308

  Fly   300 PPPQMTPQPP 309
            |||   |.||
Human   309 PPP---PLPP 315

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Dll	NP_001137759.1	Homeodomain	125..181	CDD:459649	32/55 (58%)
BARHL1	NP_064448.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..90
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	112..184		21/79 (27%)
		Homeodomain	179..235	CDD:459649	32/55 (58%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	305..327		6/14 (43%)