Protein Alignment Dll and PITX3

DIOPT Version :10

• Sequence 1: NP_001137759.1
• Gene: Dll / 37973
• FlyBaseID: FBgn0000157
• Length: 347
• Species: Drosophila melanogaster
• Sequence 2: NP_005020.1
• Gene: PITX3 / 5309
• HGNCID: 9006
• Length: 302
• Species: Homo sapiens
• Alignment Length: 248
• Identity: 71/248 - (28%)
• Similarity: 100/248 - (40%)
• Gaps: 61/248 - (24%)

  Fly    62 DSGFPSPRSALGYPFPPMH---QNSYSGYHLGSYAPPCASPPKDDFSISDKCEDSGLRVNGKGKK 123
            |:|.|.|:.       |.|   ...:|.....|.:.|..||           ||..|:     ||
Human    20 DAGTPHPQL-------PEHGCKGQEHSDSEKASASLPGGSP-----------EDGSLK-----KK 61

  Fly   124 MRKPRTIYSSLQLQQLNRRFQRTQYLALPERAELAASLGLTQTQVKIWFQNRRSKYKKMMKAAQG 188
            .|:.||.::|.|||:|...|||.:|..:..|.|:|....||:.:|::||:|||:|::|..::.|.
Human    62 QRRQRTHFTSQQLQELEATFQRNRYPDMSTREEIAVWTNLTEARVRVWFKNRRAKWRKRERSQQA 126

  Fly   189 PGTNSGM--PLGGGGP-----NPGQ---HSPNQMHSGELANGRFLWAALETN-GTLALVHSTGGN 242
            .......  ||||..|     .||.   :.|.:..:..||...|.:|....| |.||
Human   127 ELCKGSFAAPLGGLVPPYEEVYPGYSYGNWPPKALAPPLAAKTFPFAFNSVNVGPLA-------- 183

  Fly   243 NGGGSNSGSPSHYLPPGHSPTPSSTPVSELSPEFPP-------TGLSPPTQAP 288
                    |...:.||. |...|..|.:..:|...|       .|..||..||
Human   184 --------SQPVFSPPS-SIAASMVPSAAAAPGTVPGPGALQGLGGGPPGLAP 227

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Dll	NP_001137759.1	Homeodomain	125..181	CDD:459649	24/55 (44%)
PITX3	NP_005020.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..71		19/73 (26%)
		Homeodomain	63..119	CDD:459649	24/55 (44%)
		OAR	258..275	CDD:461067
		OAR. /evidence=ECO:0000255|PROSITE-ProRule:PRU00138	262..275
		Nuclear localization signal. /evidence=ECO:0000255	268..272