Protein Alignment Dll and PITX1

DIOPT Version :10

• Sequence 1: NP_001137759.1
• Gene: Dll / 37973
• FlyBaseID: FBgn0000157
• Length: 347
• Species: Drosophila melanogaster
• Sequence 2: XP_047273274.1
• Gene: PITX1 / 5307
• HGNCID: 9004
• Length: 348
• Species: Homo sapiens
• Alignment Length: 300
• Identity: 75/300 - (25%)
• Similarity: 113/300 - (37%)
• Gaps: 92/300 - (30%)

  Fly    46 GGIRSTYQHFGPQGGQDSGFPSPRSA-------------LGYPFPPMHQNSYSGYHLGSYAPP-- 95
            ||.|.     .|..|..:..|:...|             |..|.||.|... ..:||...|.|
Human    17 GGARP-----APAPGAPAAVPTSMDAFKGGMSLERLPEGLRPPPPPPHDMG-PAFHLARPADPRE 75

  Fly    96 ---CASPPKDDFSISDK--------CEDSGLRVNG--------KGKKMRKPRTIYSSLQLQQLNR 141
               .::....|..:.:|        .||||....|        |.||.|:.||.::|.|||:|..
Human    76 PLENSASESSDTELPEKERGGEPKGPEDSGAGGTGCGGADDPAKKKKQRRQRTHFTSQQLQELEA 140

  Fly   142 RFQRTQYLALPERAELAASLGLTQTQVKIWFQNRRSKYKKMMKAAQGPGTNSGMPLGGGGPNP-- 204
            .|||.:|..:..|.|:|....||:.:|::||:|||:|::|..:       |..:.|..||..|
Human   141 TFQRNRYPDMSMREEIAVWTNLTEPRVRVWFKNRRAKWRKRER-------NQQLDLCKGGYVPQF 198

  Fly   205 ------------GQHSPNQMHSGELA------------------NGRFLWAALETNGTLALVHST 239
                        ..:|.|...:..||                  :.:.:::|..:..::.:..|.
Human   199 SGLVQPYEDVYAAGYSYNNWAAKSLAPAPLSTKSFTFFNSMSPLSSQSMFSAPSSISSMTMPSSM 263

  Fly   240 G-GNNGGGSNSG----------SPSHYLPPGHSP--TPSS 266
            | |...|..|||          |.:..:.||..|  ||:|
Human   264 GPGAVPGMPNSGLNNINNLTGSSLNSAMSPGACPYGTPAS 303

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Dll	NP_001137759.1	Homeodomain	125..181	CDD:459649	24/55 (44%)
PITX1	XP_047273274.1	Homeodomain	124..180	CDD:459649	24/55 (44%)
		OAR	310..327	CDD:461067