Protein Alignment Dll and DBX2

DIOPT Version :10

• Sequence 1: NP_001137759.1
• Gene: Dll / 37973
• FlyBaseID: FBgn0000157
• Length: 347
• Species: Drosophila melanogaster
• Sequence 2: NP_001004329.2
• Gene: DBX2 / 440097
• HGNCID: 33186
• Length: 339
• Species: Homo sapiens
• Alignment Length: 312
• Identity: 82/312 - (26%)
• Similarity: 116/312 - (37%)
• Gaps: 92/312 - (29%)

  Fly     4 PDAPHTPKYMDGGNTAASVTPGIN---IPGKSAFVEL----QQHAAAG--YGGIRSTYQHFGPQ- 58
            |.|||.|       ..|..|.|..   :|.....::|    :|.:.||  | |.|..:|...|.
Human    56 PPAPHDP-------ATALATAGAQLRPLPASPVPLKLCPAAEQVSPAGAPY-GTRWAFQVLSPSA 112

  Fly    59 ----------GGQDSGFPSPRSALGYPF----PPMHQNSYSGYHLGSYAPPCASP--PKDDFSIS 107
                      |.:|..|.....|...||    ||.    ||....||...|.:|.  |:::..:.
Human   113 DSARLPGRAPGDRDCTFQPSAPAPSKPFLLSTPPF----YSACCGGSCRRPASSTAFPREESMLP 173

  Fly   108 DKCEDSGLRVNGKGKKMRKPRTIYSSLQLQQLNRRFQRTQYLALPERAELAASLGLTQTQVKIWF 172
            ...:||    |.|.::....|.::|..|.:.|.:.||:.:|::..:|.:||.:|||.::||||||
Human   174 LLTQDS----NSKARRGILRRAVFSEDQRKALEKMFQKQKYISKTDRKKLAINLGLKESQVKIWF 234

  Fly   173 QNRR-----SKYKKMM--KAAQGPGTN----SGMPLGGGGPNPGQHSPNQMHSGELANGRFLWAA 226
            ||||     ||.|:::  :..|..|..    |...||...|.|......|.||..      .|..
Human   235 QNRRMKWRNSKEKEVLSNRCIQEVGLQEDPLSRSALGFPSPCPSIWDVPQQHSSP------RWRE 293

  Fly   227 LETNGTLALVHSTGGNNGGGSNSGSPSHYLPPGHSPTPSSTPVSELSPEFPP 278
                                             :||.||...:.|.|...||
Human   294 ---------------------------------NSPEPSERLIQESSGAPPP 312

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Dll	NP_001137759.1	Homeodomain	125..181	CDD:459649	25/60 (42%)
DBX2	NP_001004329.2	PRK12323	<3..>146	CDD:481241	24/97 (25%)
		Homeodomain	189..243	CDD:459649	23/53 (43%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	282..318		12/70 (17%)