Protein Alignment Dll and NKX1-2

DIOPT Version :10

• Sequence 1: NP_001137759.1
• Gene: Dll / 37973
• FlyBaseID: FBgn0000157
• Length: 347
• Species: Drosophila melanogaster
• Sequence 2: NP_001139812.1
• Gene: NKX1-2 / 390010
• HGNCID: 31652
• Length: 310
• Species: Homo sapiens
• Alignment Length: 335
• Identity: 95/335 - (28%)
• Similarity: 125/335 - (37%)
• Gaps: 127/335 - (37%)

  Fly     1 MDAPDAPHTPKYMDGGNTAASVTPGINIPGKSAFVE----------LQQHAAAGYGGIRSTYQHF 55
            ::.|||        .|..|...:|   :.|..|..|          |::.||....|:..:..
Human    68 LETPDA--------AGPGAGQASP---LEGSEAEEEEDAEDPRRPRLRERAARLLPGLARSPD-- 119

  Fly    56 GPQGGQDSGFP----------SPRSALGYPFPPMHQNSYSGYHLGSYAPPCASPPKDDFSISDKC 110
            .|.|...||.|          ||..:.|.|.|...:          ..|.||.|
Human   120 APAGALASGEPCEDGGGGPVRSPPGSPGSPRPRRRR----------LEPNCAKP----------- 163

  Fly   111 EDSGLRVNGKGKKMRKPRTIYSSLQLQQLNRRFQRTQYLALPERAELAASLGLTQTQVKIWFQNR 175
                          |:.||.::..||..|..:|:.|:||::.||..||.||.||:||||||||||
Human   164 --------------RRARTAFTYEQLVALENKFRATRYLSVCERLNLALSLSLTETQVKIWFQNR 214

  Fly   176 RSKYKKMMKAAQGPGTNSGMPLGGGGPNPGQHSPNQMHSGELANGRFLWAALETNGTLALVHSTG 240
            |:|:||     |.||.:....:|||.|.||                                :.|
Human   215 RTKWKK-----QNPGADGAAQVGGGAPQPG--------------------------------AAG 242

  Fly   241 GNNGGGSNSGSPSHYLPPG----HSPT-PSSTPVSELSP---EFPPTGLSPPTQ-APWDQKPHWI 296
            |..|||| .|||.   |||    |..| ||.:..:.|.|   .||.|..:|.:. ||:
Human   243 GGGGGGS-GGSPG---PPGTGALHFQTFPSYSAANVLFPSAASFPLTAAAPGSPFAPF------- 296

  Fly   297 DHKPPPQMTP 306
              ..|..:||
Human   297 --LGPSYLTP 304

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Dll	NP_001137759.1	Homeodomain	125..181	CDD:459649	30/55 (55%)
NKX1-2	NP_001139812.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	36..165		27/144 (19%)
		Homeodomain	164..220	CDD:459649	30/55 (55%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	217..260		24/83 (29%)