Protein Alignment Dll and PDX1

DIOPT Version :10

• Sequence 1: NP_001137759.1
• Gene: Dll / 37973
• FlyBaseID: FBgn0000157
• Length: 347
• Species: Drosophila melanogaster
• Sequence 2: NP_000200.1
• Gene: PDX1 / 3651
• HGNCID: 6107
• Length: 283
• Species: Homo sapiens
• Alignment Length: 232
• Identity: 64/232 - (27%)
• Similarity: 92/232 - (39%)
• Gaps: 61/232 - (26%)

  Fly    57 PQGGQDSGFPSPRSALGYPFPPMH-------QNSYSGYHLGSYAPPCASPPKDDFSISDKCEDSG 114
            |:|.:......| :.:..|||.|.       :..::|   |:||   |.|.::
Human   101 PEGAEPGVLEEP-NRVQLPFPWMKSTKAHAWKGQWAG---GAYA---AEPEEN------------ 146

  Fly   115 LRVNGKGKKMRKPRTIYSSLQLQQLNRRFQRTQYLALPERAELAASLGLTQTQVKIWFQNRRSKY 179
                      ::.||.|:..||.:|.:.|...:|::.|.|.|||..|.||:..:||||||||.|:
Human   147 ----------KRTRTAYTRAQLLELEKEFLFNKYISRPRRVELAVMLNLTERHIKIWFQNRRMKW 201

  Fly   180 KKMMKAAQGPGTNSGMPLGGGGPNPGQHSPNQMHSGELANGRFLWAALETNGTLALVHSTGGNNG 244
            ||.....:|.||..|   |||...|.|.                  ...|:|...|........|
Human   202 KKEEDKKRGGGTAVG---GGGVAEPEQD------------------CAVTSGEELLALPPPPPPG 245

  Fly   245 GGSNSGSP----SHYLPPGHSPTPSSTPVSELSPEFP 277
            |.....:|    ...||||.|.:|..:.|:...|:.|
Human   246 GAVPPAAPVAAREGRLPPGLSASPQPSSVAPRRPQEP 282

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Dll	NP_001137759.1	Homeodomain	125..181	CDD:459649	25/55 (45%)
PDX1	NP_000200.1	Transactivation domain. /evidence=ECO:0000250	13..73
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	34..71
		Antp-type hexapeptide	118..123		3/4 (75%)
		Homeodomain	147..203	CDD:459649	25/55 (45%)
		Nuclear localization signal. /evidence=ECO:0000250	197..203		3/5 (60%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	201..283		26/103 (25%)