DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Dll and NOTO

DIOPT Version :9

Sequence 1:	NP_001137759.1	Gene:	Dll / 37973	FlyBaseID:	FBgn0000157	Length:	347	Species:	Drosophila melanogaster
Sequence 2:	NP_001127934.1	Gene:	NOTO / 344022	HGNCID:	31839	Length:	251	Species:	Homo sapiens

Alignment Length:	207	Identity:	55/207 - (26%)
Similarity:	84/207 - (40%)	Gaps:	47/207 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 APDAPHTPKYMDGGNTAASV----------TPGINIPGKSAFVELQQHAAAGY---GGIRSTYQH 54
            :|..|:||:......:..||          .|..:.|..||.|......||..   ||:
Human    32 SPTGPNTPRAPGRFESPFSVEAILARPDPCAPAASQPSGSACVHPAFWTAASLCATGGL------ 90

  Fly    55 FGPQGGQDSGFPSPRSALGYPFPPMHQNSYSG------------YHLGSYAPPCASPPKDDFSIS 107
              |.....|..|:..|...||.|........|            :..|.:|.|..:|.:|
Human    91 --PWACPTSWLPAYLSVGFYPVPGPRVAPVCGLLGFGVTGLELAHCSGLWAFPDWAPTED----- 148

  Fly   108 DKCEDSGLRVNGKGKKMRKPRTIYSSLQLQQLNRRFQRTQYLALPERAELAASLGLTQTQVKIWF 172
                     :....::.::.||:::..||::|.:.|.:...|...:||:|||.|.||:.||::||
Human   149 ---------LQDTERQQKRVRTMFNLEQLEELEKVFAKQHNLVGKKRAQLAARLKLTENQVRVWF 204

  Fly   173 QNRRSKYKKMMK 184
            ||||.||:|..|
Human   205 QNRRVKYQKQQK 216

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dll	NP_001137759.1	Homeobox	127..180	CDD:278475	24/52 (46%)
NOTO	NP_001127934.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..47		4/14 (29%)
		Homeobox	160..211	CDD:278475	23/50 (46%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	224..251
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0850
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810