DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Dll and HOXD13

DIOPT Version :9

Sequence 1:	NP_001137759.1	Gene:	Dll / 37973	FlyBaseID:	FBgn0000157	Length:	347	Species:	Drosophila melanogaster
Sequence 2:	NP_000514.2	Gene:	HOXD13 / 3239	HGNCID:	5136	Length:	343	Species:	Homo sapiens

Alignment Length:	206	Identity:	55/206 - (26%)
Similarity:	82/206 - (39%)	Gaps:	52/206 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 APH-------TPKYMDGGNTAASVTPGINIPGKSAFVELQQHAAAGYGGIRSTYQHFGPQGGQDS 63
            :||       ..||||....|:|..|...:|.::..|..       |.|..|.|||.       .
Human   154 SPHASLGGFPVEKYMDVSGLASSSVPANEVPARAKEVSF-------YQGYTSPYQHV-------P 204

  Fly    64 GFPSPRSALGYPFPPMHQN--SYSGYH-------------------LGSYAPPCASPPKDDFSIS 107
            |:....|..| ...|.|:.  |..||.                   .||:....:.|.....:..
Human   205 GYIDMVSTFG-SGEPRHEAYISMEGYQSWTLANGWNSQVYCTKDQPQGSHFWKSSFPGDVALNQP 268

  Fly   108 DKCEDSGLRVNGKGKKMRKPRTIYSSLQLQQLNRRFQRTQYLALPERAELAASLGLTQTQVKIWF 172
            |.|      |..:|:|.|.|   |:.|||::|...:...:::...:|..::|:..|::.||.|||
Human   269 DMC------VYRRGRKKRVP---YTKLQLKELENEYAINKFINKDKRRRISAATNLSERQVTIWF 324

  Fly   173 QNRRSKYKKMM 183
            ||||.|.||::
Human   325 QNRRVKDKKIV 335

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dll	NP_001137759.1	Homeobox	127..180	CDD:278475	19/52 (37%)
HOXD13	NP_000514.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..28
		HoxA13_N	39..174	CDD:289085	6/19 (32%)
		polyalanine repeat	57..71
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	78..115
		homeodomain	277..333	CDD:238039	21/58 (36%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.910