DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Dll and HOXC13

DIOPT Version :9

Sequence 1:	NP_001137759.1	Gene:	Dll / 37973	FlyBaseID:	FBgn0000157	Length:	347	Species:	Drosophila melanogaster
Sequence 2:	NP_059106.2	Gene:	HOXC13 / 3229	HGNCID:	5125	Length:	330	Species:	Homo sapiens

Alignment Length:	196	Identity:	50/196 - (25%)
Similarity:	80/196 - (40%)	Gaps:	64/196 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 PKYMDGGNTAASVTPGIN---IPGKSAFVELQQHAAAGYGGIRSTYQHFGPQGGQDS----GFPS 67
            |.|:|     .||.|||:   .|...|.:.::            .|||:....|.||    ....
Human   186 PGYLD-----VSVVPGISGHPEPRHDALIPVE------------GYQHWALSNGWDSQVYCSKEQ 233

  Fly    68 PRSALGY--PFP---PMHQNSYSGYHLGSYAPPCASPPKDDFSISDKCEDSGLRVNGKGKKMRKP 127
            .:||..:  |||   |: |...|.|..|                                  ||.
Human   234 SQSAHLWKSPFPDVVPL-QPEVSSYRRG----------------------------------RKK 263

  Fly   128 RTIYSSLQLQQLNRRFQRTQYLALPERAELAASLGLTQTQVKIWFQNRRSKYKKMMKAAQGPGTN 192
            |..|:.:||::|.:.:..::::...:|..::|:..|::.||.|||||||.|.||::..::.|..:
Human   264 RVPYTKVQLKELEKEYAASKFITKEKRRRISATTNLSERQVTIWFQNRRVKEKKVVSKSKAPHLH 328

  Fly   193 S 193
            |
Human   329 S 329

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dll	NP_001137759.1	Homeobox	127..180	CDD:278475	18/52 (35%)
HOXC13	NP_059106.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	30..50
		HoxA13_N	54..166	CDD:315049
		HOX	260..312	CDD:197696	18/85 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910