Protein Alignment Dll and HHEX

DIOPT Version :10

• Sequence 1: NP_001137759.1
• Gene: Dll / 37973
• FlyBaseID: FBgn0000157
• Length: 347
• Species: Drosophila melanogaster
• Sequence 2: NP_002720.1
• Gene: HHEX / 3087
• HGNCID: 4901
• Length: 270
• Species: Homo sapiens
• Alignment Length: 243
• Identity: 56/243 - (23%)
• Similarity: 92/243 - (37%)
• Gaps: 80/243 - (32%)

  Fly     9 TPKYMDG--GNTAASVTPGINIPG-KSAFVELQQ------------HAAAGYGGIRSTYQHFGPQ 58
            ||.|::.  |...|:.||...:|. .|:|..|..            |.|..:....:....:||.
Human    30 TPFYIEDILGRGPAAPTPAPTLPSPNSSFTSLVSPYRTPVYEPTPIHPAFSHHSAAALAAAYGPG 94

  Fly    59 GGQDSGFPSPRSALGY-----------------PF--PPMHQNSYSGYHLGSYAPPCASPPKDDF 104
            |.....:|.||:...|                 ||  .|:|:.
Human    95 GFGGPLYPFPRTVNDYTHALLRHDPLGKPLLWSPFLQRPLHKR---------------------- 137

  Fly   105 SISDKCEDSGLRVNGKGKKMRKPRTIYSSLQLQQLNRRFQRTQYLALPERAELAASLGLTQTQVK 169
                           ||.::|     :|:.|..:|.::|:..:||:.|||..||..|.|::.|||
Human   138 ---------------KGGQVR-----FSNDQTIELEKKFETQKYLSPPERKRLAKMLQLSERQVK 182

  Fly   170 IWFQNRRSKYKKMMKAAQGPGTNSGMPLGG--GGPNPGQHSPNQMHSG 215
            .||||||:|::::.:  :.|.:|....|..  ...:..|..|::.:.|
Human   183 TWFQNRRAKWRRLKQ--ENPQSNKKEELESLDSSCDQRQDLPSEQNKG 228

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Dll	NP_001137759.1	Homeodomain	125..181	CDD:459649	24/55 (44%)
HHEX	NP_002720.1	Interaction with SOX13. /evidence=ECO:0000269|PubMed:20028982	1..137		24/106 (23%)
		Homeodomain	136..194	CDD:459649	26/99 (26%)
		Required for WNT signaling induction. /evidence=ECO:0000269|PubMed:20028982	137..270		32/136 (24%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	194..270		6/37 (16%)