DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Dll and dlx3b

DIOPT Version :9

Sequence 1:	NP_001137759.1	Gene:	Dll / 37973	FlyBaseID:	FBgn0000157	Length:	347	Species:	Drosophila melanogaster
Sequence 2:	NP_571397.2	Gene:	dlx3b / 30585	ZFINID:	ZDB-GENE-980526-280	Length:	269	Species:	Danio rerio

Alignment Length:	348	Identity:	114/348 - (32%)
Similarity:	140/348 - (40%)	Gaps:	113/348 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 GNTAASVTPGINI---------PGKSAFVELQQHAAAGYGGIRSTYQHFGPQGGQDSGFPSPRSA 71
            |.|.....|||:.         |.......|.:.:|...|...|.:::          :.||
Zfish     3 GPTYDRKIPGISTDLSGSMSCHPTSKDSPTLPESSATDMGYYSSHHEY----------YQSP--- 54

  Fly    72 LGYPFPPMHQNSYSGYHL-GSYAPPCASPPKDDF---------------------SISDKCEDSG 114
               |: |...|||..::| |..|.|.|.|.|.::                     ::.::.|...
Zfish    55 ---PY-PQQMNSYHQFNLSGMGATPGAYPTKTEYPYNTYRQYGHYNRDLQTPPQSAVKEEPETEV 115

  Fly   115 LRVNGKGKKMRKPRTIYSSLQLQQLNRRFQRTQYLALPERAELAASLGLTQTQVKIWFQNRRSKY 179
            ..||||.||:|||||||||.||..|.||||:.|||||||||||||.||||||||||||||||||:
Zfish   116 RMVNGKPKKIRKPRTIYSSYQLAALQRRFQKAQYLALPERAELAAQLGLTQTQVKIWFQNRRSKF 180

  Fly   180 KKMMKAAQGPGTNSGMPLGGGGPNPGQHSPNQMHSGELANGRFLWAALETNGTLALVHSTGGNNG 244
            ||:.|       |..:||        :||||...| ...|.....|..:.|     .||:..|.|
Zfish   181 KKLYK-------NGEVPL--------EHSPNASDS-MACNSPPSPAVWDNN-----AHSSQVNRG 224

  Fly   245 GGSNSGSPSHYLPPGHSPTPSSTPVSELSPEFPPTGLSPPTQAPWDQKPHWIDHKPPPQMTPQPP 309
                      .:|.                  ||...:||...  |...||.      |......
Zfish   225 ----------QIPQ------------------PPLSSTPPYME--DYSNHWY------QQGSHLQ 253

  Fly   310 HPAATLHPQTHHHNPPPQMGGYV 332
            ||.        ||..|||..|.|
Zfish   254 HPV--------HHPGPPQSVGAV 268

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dll	NP_001137759.1	Homeobox	127..180	CDD:278475	45/52 (87%)
dlx3b	NP_571397.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..41		8/37 (22%)
		DLL_N	28..104	CDD:289198	18/92 (20%)
		Homeobox	128..181	CDD:278475	45/52 (87%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	191..242		19/94 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	250..269		9/27 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170588202
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0850
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1416398at2759
OrthoFinder	1	1.000	-	-		FOG0000655
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24327
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	7	6.850