DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Dll and dlx4b

DIOPT Version :9

Sequence 1:	NP_001137759.1	Gene:	Dll / 37973	FlyBaseID:	FBgn0000157	Length:	347	Species:	Drosophila melanogaster
Sequence 2:	NP_571393.1	Gene:	dlx4b / 30581	ZFINID:	ZDB-GENE-990415-50	Length:	254	Species:	Danio rerio

Alignment Length:	268	Identity:	107/268 - (39%)
Similarity:	135/268 - (50%)	Gaps:	66/268 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 PGKSAFVELQQHAAAGYGGIRSTYQHFG-------PQGGQDSG------FPSPRSA------LGY 74
            |.||||:|.      |: |:.|..||..       |..|..||      .|.|.||      |||
Zfish    16 PSKSAFLEF------GH-GLASNQQHLSGFAHNIYPVHGLHSGGHLQHDAPYPSSAPHYSRPLGY 73

  Fly    75 PFP-PMH---QNSYSGYHLGSYAPPCASPPKDDFSISDKC--EDSGLRVNGKGKKMRKPRTIYSS 133
            .:| |:.   ..:|..|...:::...|....:|.:.....  |:..:|:||||||:|||||||||
Zfish    74 AYPGPVSAAAPGAYMPYQPNNHSGALAHTRAEDTNHEKPAVIENGEIRLNGKGKKIRKPRTIYSS 138

  Fly   134 LQLQQLNRRFQRTQYLALPERAELAASLGLTQTQVKIWFQNRRSKYKKMMK-AAQGP-----GTN 192
            :|||.|::|||:||||||||||:|||.||||||||||||||:||||||:|| .:.||     .|:
Zfish   139 VQLQALHQRFQQTQYLALPERADLAAKLGLTQTQVKIWFQNKRSKYKKIMKHGSSGPEGELLHTS 203

  Fly   193 SGMPLGGGGPNPGQHSPNQMHSGELANGRFLWAALETNGTLALVHSTGGNNGGGSNSGSPSHYLP 257
            |..|.     :||...              ||.....|....:..|:..||.|        |:.|
Zfish   204 SSSPC-----SPGLSQ--------------LWEVSMANKVPPMHPSSYMNNYG--------HWYP 241

  Fly   258 PGH-SPTP 264
            |.| .|.|
Zfish   242 PHHQDPVP 249

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dll	NP_001137759.1	Homeobox	127..180	CDD:278475	44/52 (85%)
dlx4b	NP_571393.1	Homeobox	132..185	CDD:278475	44/52 (85%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170588203
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0850
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	144	1.000	Inparanoid score	I4422
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1416398at2759
OrthoFinder	1	1.000	-	-		FOG0000655
OrthoInspector	1	1.000	-	-		otm25468
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24327
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X884
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	11	10.860