DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Dll and dlx1a

DIOPT Version :9

Sequence 1:	NP_001137759.1	Gene:	Dll / 37973	FlyBaseID:	FBgn0000157	Length:	347	Species:	Drosophila melanogaster
Sequence 2:	NP_571380.1	Gene:	dlx1a / 30568	ZFINID:	ZDB-GENE-990415-48	Length:	252	Species:	Danio rerio

Alignment Length:	319	Identity:	114/319 - (35%)
Similarity:	147/319 - (46%)	Gaps:	101/319 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 TAASVTPGINIP--GKSAFVEL----QQHAAAGYGGIRSTYQHFG---------PQGGQDSGF-P 66
            |.:::...:|.|  |||.|:|.    ||.:.:.     .|:.|:.         ||  .||.: |
Zfish     2 TMSTIPESLNSPVSGKSVFMEFGPPSQQMSPSS-----MTHGHYSMHCLHSSGHPQ--HDSAYSP 59

  Fly    67 SPRSALGYPFPPMHQNSYSGYHLGSYAPPCASPPKDDFSISDKCEDSG-------------LRVN 118
            :|......|:|  :.||...:....|.....:.|.:......:.||..             :|.|
Zfish    60 APSFPRSLPYP--YVNSVGSHSSSPYLSTVQTYPNNSALAQTRLEDPAPESEKNTVVEGGEVRFN 122

  Fly   119 GKGKKMRKPRTIYSSLQLQQLNRRFQRTQYLALPERAELAASLGLTQTQVKIWFQNRRSKYKKMM 183
            |||||:|||||||||||||.||||||:|||||||||||||||||||||||||||||:|||:||:|
Zfish   123 GKGKKIRKPRTIYSSLQLQALNRRFQQTQYLALPERAELAASLGLTQTQVKIWFQNKRSKFKKLM 187

  Fly   184 KAAQGPGTNSGMPLGGGGPNPGQHSPNQMHSGELANGRFLWAALETNGTLALVHSTGGNNGGGSN 248
            |  ||.||                    :.:..|||||                        |.:
Zfish   188 K--QGGGT--------------------IDTNALANGR------------------------GLS 206

  Fly   249 SGSPSHYLPPGHSPT---PSSTPVSELSPEFPPTGLSPPTQAPWDQKPHWIDHKPPPQM 304
            :||||  :.|..:.|   .:|||.|.:           |:...|....|. |....||:
Zfish   207 TGSPS--VAPVWNTTATVKTSTPTSYI-----------PSYTSWYPTAHQ-DTMQQPQL 251

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dll	NP_001137759.1	Homeobox	127..180	CDD:278475	49/52 (94%)
dlx1a	NP_571380.1	COG5576	<124..233	CDD:227863	79/167 (47%)
dlx1a	NP_571380.1	Homeobox	131..184	CDD:278475	49/52 (94%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170588197
Domainoid	1	1.000	109	1.000	Domainoid score	I6305
eggNOG	1	0.900	-	-		E1_KOG0850
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	144	1.000	Inparanoid score	I4422
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1416398at2759
OrthoFinder	1	1.000	-	-		FOG0000655
OrthoInspector	1	1.000	-	-		otm25468
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24327
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2574
SonicParanoid	1	1.000	-	-		X884
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	11	10.980