DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Dll and dlx4a

DIOPT Version :9

Sequence 1:	NP_001137759.1	Gene:	Dll / 37973	FlyBaseID:	FBgn0000157	Length:	347	Species:	Drosophila melanogaster
Sequence 2:	NP_571375.1	Gene:	dlx4a / 30561	ZFINID:	ZDB-GENE-980526-73	Length:	250	Species:	Danio rerio

Alignment Length:	229	Identity:	101/229 - (44%)
Similarity:	127/229 - (55%)	Gaps:	41/229 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 PGKSAFVEL-------QQHAAAGYGGIRSTYQ-----HFGPQGGQDSGFPSPRSALGYPFPPMHQ 81
            |.||||:|.       |||:.    |:...:.     |.|.....|:.| || .|..|..|..:.
Zfish    15 PSKSAFLEFSHGYQSHQQHSP----GVSHAHYPVHGLHQGAHSQYDAAF-SP-GAASYSRPLAYH 73

  Fly    82 NSYSGYHLGSYAP----PCASPPKDDFSISDK---CEDSGLRVNGKGKKMRKPRTIYSSLQLQQL 139
            .|.:.:|.|:|.|    ......:.:.:.|:|   .|...:|:||||||:|||||||||||||.|
Zfish    74 YSTAHHHPGAYLPYQHNSAVGYSRVEDADSEKQSSIESGEIRLNGKGKKIRKPRTIYSSLQLQAL 138

  Fly   140 NRRFQRTQYLALPERAELAASLGLTQTQVKIWFQNRRSKYKKMMK-AAQGP-------GTNSGMP 196
            |:|||:||||||||||:|||.||||||||||||||:||||||:|| .:.||       .:.||.|
Zfish   139 NQRFQQTQYLALPERADLAAKLGLTQTQVKIWFQNKRSKYKKIMKHGSSGPEGEHLQAASASGAP 203

  Fly   197 LGGGGP------NPGQHSPNQMHSGELANGRFLW 224
            ...|.|      .|.:.:|  :|||...|....|
Zfish   204 CSPGMPPLWDVSMPSKGAP--IHSGGYMNSFGHW 235

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dll	NP_001137759.1	Homeobox	127..180	CDD:278475	46/52 (88%)
dlx4a	NP_571375.1	COG5576	98..206	CDD:227863	68/107 (64%)
		Homeobox	126..179	CDD:278475	46/52 (88%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	182..202		5/19 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170588204
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0850
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	144	1.000	Inparanoid score	I4422
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1416398at2759
OrthoFinder	1	1.000	-	-		FOG0000655
OrthoInspector	1	1.000	-	-		otm25468
orthoMCL	1	0.900	-	-		OOG6_111810
Panther	1	1.100	-	-	O	PTHR24327
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2574
SonicParanoid	1	1.000	-	-		X884
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	13	12.790