Protein Alignment Dll and pitx2

DIOPT Version :10

• Sequence 1: NP_001137759.1
• Gene: Dll / 37973
• FlyBaseID: FBgn0000157
• Length: 347
• Species: Drosophila melanogaster
• Sequence 2: NP_571050.1
• Gene: pitx2 / 30164
• ZFINID: ZDB-GENE-990714-27
• Length: 314
• Species: Danio rerio
• Alignment Length: 283
• Identity: 73/283 - (25%)
• Similarity: 117/283 - (41%)
• Gaps: 50/283 - (17%)

  Fly    78 PMHQNSYSGYHLGSYAPPCASPPKDDFSI-----SDKCEDSGLRVN---GKGKKMRKPRTIYSSL 134
            |:.::..|.:.|..:.....|.|:   |:     ..|.|||    |   .|.|:.|:.||.::|.
Zfish    35 PLQRSVDSKHRLDVHTVSDTSSPE---SVEKEKGQSKNEDS----NDDPSKKKRQRRQRTHFTSQ 92

  Fly   135 QLQQLNRRFQRTQYLALPERAELAASLGLTQTQVKIWFQNRRSKYKKMMKAAQGPGTNSGMPLGG 199
            |||:|...|||.:|..:..|.|:|....||:.:|::||:|||:|::|..:..|.....:|.
Zfish    93 QLQELEATFQRNRYPDMSTREEIAVWTNLTEARVRVWFKNRRAKWRKRERNQQAELCKNGF---- 153

  Fly   200 GGPN-PGQHSP-NQMHSGELANGRFLWAALE-TNGTLALVHSTGGNNGGGSNSGSPSHYLPPG-- 259
             ||. .|...| :.|:.....|.   |||.. |:.:|:.......|:...:...|.:.:.||.
Zfish   154 -GPQFNGLMQPYDDMYPSYTYNN---WAAKGLTSASLSTKSFPFFNSMNVNPLSSQTMFSPPNSI 214

  Fly   260 HSPTPSSTPVSELSPEFPPTGLSPPTQAPWDQKPHWIDHKPPPQMTPQPPHPAATLHPQTHHHNP 324
            .|.:.||:.|.......|.:.|:....         :::...|.:....|.||....|.|
Zfish   215 SSMSMSSSMVPSAVTGVPGSSLNSLNN---------LNNLSNPSLNSGVPTPACPYAPPT----- 265

  Fly   325 PPQMGGYVPQYWYQPETNPSLVT 347
                    |.|.|:...|.||.:
Zfish   266 --------PPYVYRDTCNSSLAS 280

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Dll	NP_001137759.1	Homeodomain	125..181	CDD:459649	24/55 (44%)
pitx2	NP_571050.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..93		17/64 (27%)
		Homeodomain	83..139	CDD:459649	24/55 (44%)
		OAR	272..289	CDD:461067	3/9 (33%)
		OAR. /evidence=ECO:0000255|PROSITE-ProRule:PRU00138	276..289		2/5 (40%)
		Nuclear localization signal. /evidence=ECO:0000255	282..286