Protein Alignment Dll and RAX

DIOPT Version :10

• Sequence 1: NP_001137759.1
• Gene: Dll / 37973
• FlyBaseID: FBgn0000157
• Length: 347
• Species: Drosophila melanogaster
• Sequence 2: NP_038463.2
• Gene: RAX / 30062
• HGNCID: 18662
• Length: 346
• Species: Homo sapiens
• Alignment Length: 274
• Identity: 68/274 - (24%)
• Similarity: 105/274 - (38%)
• Gaps: 68/274 - (24%)

  Fly    58 QGGQDSGFPSPRSALGYPFPPMHQNSYSGYHLGSYAPPCASPPKDDFSISDKCEDSGLRVNGKGK 122
            :|.:.|..|:|..|..|..|..:.....|....|...| ..|...:..:|::.:..        |
Human    79 EGSEPSPPPAPAPAPEYEAPRPYCPKEPGEARPSPGLP-VGPATGEAKLSEEEQPK--------K 134

  Fly   123 KMRKPRTIYSSLQLQQLNRRFQRTQYLALPERAELAASLGLTQTQVKIWFQNRRSKYKK------ 181
            |.|:.||.:::.||.:|.|.|:::.|..:..|.|||..:.|.:.:|::||||||:|:::
Human   135 KHRRNRTTFTTYQLHELERAFEKSHYPDVYSREELAGKVNLPEVRVQVWFQNRRAKWRRQEKLEV 199

  Fly   182 ---------MMKAAQGPGTNSGMPLG-----GGGPNPGQHSPNQMHSGELANGRFLWAALETNGT 232
                     ::..::.|.:.:..|||     ||||                          ..|.
Human   200 SSMKLQDSPLLSFSRSPPSATLSPLGAGPGSGGGP--------------------------AGGA 238

  Fly   233 LALVHSTGGNNGGGSNSGSPSHYLPPGHSPTPSSTPVSELSPEFPPTGLSPPTQAPWDQKPHWID 297
            |.|....|....||   |:.:....||..|...|.|.|...|..||..|:.|...|..|
Human   239 LPLESWLGPPLPGG---GATALQSLPGFGPPAQSLPASYTPPPPPPPFLNSPPLGPGLQ------ 294

  Fly   298 HKPPPQMTPQPPHP 311
                |...|.|.:|
Human   295 ----PLAPPPPSYP 304

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Dll	NP_001137759.1	Homeodomain	125..181	CDD:459649	22/55 (40%)
RAX	NP_038463.2	Octapeptide motif	33..40
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	46..145		17/74 (23%)
		Homeodomain	137..193	CDD:459649	22/55 (40%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	194..318		32/150 (21%)
		OAR	319..335	CDD:461067
		OAR. /evidence=ECO:0000255|PROSITE-ProRule:PRU00138	323..336
		Nuclear localization signal. /evidence=ECO:0000255	329..333