Protein Alignment Dll and TLX3

DIOPT Version :10

• Sequence 1: NP_001137759.1
• Gene: Dll / 37973
• FlyBaseID: FBgn0000157
• Length: 347
• Species: Drosophila melanogaster
• Sequence 2: NP_066305.2
• Gene: TLX3 / 30012
• HGNCID: 13532
• Length: 291
• Species: Homo sapiens
• Alignment Length: 240
• Identity: 69/240 - (28%)
• Similarity: 96/240 - (40%)
• Gaps: 76/240 - (31%)

  Fly     1 MDAPDA-----PHTPKYMDGGNTAASVTPGINIPGKSAFVELQQHAAAGYGGIRSTYQHFGPQGG 60
            |:||.:     ||.|       .:..:...:|.|.:.:....:....|.|.|        ||.||
Human     1 MEAPASAQTPHPHEP-------ISFGIDQILNSPDQDSAPAPRGPDGASYLG--------GPPGG 50

  Fly    61 QDSG-FPS-PRSALGYPFPPMHQNSYSGYHLGSYAP------------PCASPP----------- 100
            :... :|| |.|..|...|.....||| .:| |.||            |.|.||
Human    51 RPGATYPSLPASFAGLGAPFEDAGSYS-VNL-SLAPAGVIRVPAHRPLPGAVPPPLPSALPAMPS 113

  Fly   101 ----------------------KDDFSISDKCEDSGL--RV-----NGKGKKMRKPRTIYSSLQL 136
                                  ||.|:.:.......:  |:     |....|.:||||.:|.:|:
Human   114 VPTVSSLGGLNFPWMESSRRFVKDRFTAAAALTPFTVTRRIGHPYQNRTPPKRKKPRTSFSRVQI 178

  Fly   137 QQLNRRFQRTQYLALPERAELAASLGLTQTQVKIWFQNRRSKYKK 181
            .:|.:||.|.:|||..|||.||.||.:|..|||.||||||:|:::
Human   179 CELEKRFHRQKYLASAERAALAKSLKMTDAQVKTWFQNRRTKWRR 223

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Dll	NP_001137759.1	Homeodomain	125..181	CDD:459649	31/55 (56%)
TLX3	NP_066305.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..56		15/69 (22%)
		Homeodomain	167..223	CDD:459649	31/55 (56%)