Protein Alignment Dll and Pitx3

DIOPT Version :10

• Sequence 1: NP_001137759.1
• Gene: Dll / 37973
• FlyBaseID: FBgn0000157
• Length: 347
• Species: Drosophila melanogaster
• Sequence 2: NP_062120.1
• Gene: Pitx3 / 29609
• RGDID: 3332
• Length: 302
• Species: Rattus norvegicus
• Alignment Length: 253
• Identity: 74/253 - (29%)
• Similarity: 106/253 - (41%)
• Gaps: 47/253 - (18%)

  Fly    55 FGPQGGQDSGFPS-PRSALGYPFPPMHQNSYSGYHLGSYAPPCASPPKDDFSISDKCEDSGLRVN 118
            ||..|..::..|: ..|..|.|.||:.::...|..........||.|      ....||..|:
  Rat     3 FGLLGEAEARSPALSLSDAGTPHPPLPEHGCKGQEHSDSEKASASLP------GGSPEDGSLK-- 59

  Fly   119 GKGKKMRKPRTIYSSLQLQQLNRRFQRTQYLALPERAELAASLGLTQTQVKIWFQNRRSKYKKMM 183
               ||.|:.||.::|.|||:|...|||.:|..:..|.|:|....||:.:|::||:|||:|::|..
  Rat    60 ---KKQRRQRTHFTSQQLQELEATFQRNRYPDMSTREEIAVWTNLTEARVRVWFKNRRAKWRKRE 121

  Fly   184 KAAQGPGTNSGM--PLGGGGP-----NPGQ---HSPNQMHSGELANGRFLWAALETN-GTLALVH 237
            ::.|......|.  ||||..|     .||.   :.|.:..:..||...|.:|....| |.||
  Rat   122 RSQQAELCKGGFAAPLGGLVPPYEEVYPGYTYGNWPPKALAPPLAAKTFPFAFNSVNVGPLA--- 183

  Fly   238 STGGNNGGGSNSGSPSHYLPPGHSPTPSSTPVSELSPEFPP-------TGLSPPTQAP 288
                         |...:.||. |...|..|.:..:|...|       .|.:||..||
  Rat   184 -------------SQPVFSPPS-SIAASMVPSAAAAPGTVPGPGALQGLGGAPPGLAP 227

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Dll	NP_001137759.1	Homeodomain	125..181	CDD:459649	24/55 (44%)
Pitx3	NP_062120.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..71		21/78 (27%)
		Homeodomain	63..119	CDD:459649	24/55 (44%)
		PTZ00395	<142..>236	CDD:185594	25/103 (24%)
		OAR	258..275	CDD:461067
		OAR. /evidence=ECO:0000255|PROSITE-ProRule:PRU00138	262..275
		Nuclear localization signal. /evidence=ECO:0000255	268..272