Protein Alignment Dll and Pdx1

DIOPT Version :10

• Sequence 1: NP_001137759.1
• Gene: Dll / 37973
• FlyBaseID: FBgn0000157
• Length: 347
• Species: Drosophila melanogaster
• Sequence 2: NP_074043.4
• Gene: Pdx1 / 29535
• RGDID: 62387
• Length: 283
• Species: Rattus norvegicus
• Alignment Length: 292
• Identity: 80/292 - (27%)
• Similarity: 112/292 - (38%)
• Gaps: 69/292 - (23%)

  Fly     4 PDAPHTPKYMDG-GNTAASVTPGIN------IPGKSAFVELQQHAAAGYGGIRSTYQHFGPQGGQ 61
            |..|..|::... |.......|.|:      :....|...|..|..|..|........| |.|.:
  Rat    42 PPPPPPPQFAGSLGTLEQGSPPDISPYEVPPLADDPAGAHLHHHLPAQLGLAHPPPGPF-PNGTE 105

  Fly    62 DSGFPSPRSALGYPFPPMH-------QNSYSGYHLGSYAPPCASPPKDDFSISDKCEDSGLRVNG 119
            ..|...| |.:..|||.|.       ::.::|   |:||   |.|.::
  Rat   106 TGGLEEP-SRVHLPFPWMKSTKAHAWKSQWAG---GAYA---AEPEEN----------------- 146

  Fly   120 KGKKMRKPRTIYSSLQLQQLNRRFQRTQYLALPERAELAASLGLTQTQVKIWFQNRRSKYKKMMK 184
                 ::.||.|:..||.:|.:.|...:|::.|.|.|||..|.||:..:||||||||.|:||...
  Rat   147 -----KRTRTAYTRAQLLELEKEFLFNKYISRPRRVELAVMLNLTERHIKIWFQNRRMKWKKEED 206

  Fly   185 AAQGPGTNSGMPLGGGGPNPGQHSPNQMHSGELANGRFLWAALETNGTLALVHSTGGNNGGGSNS 249
            ..:..||.||   ||||..|.|.                  ...|:|...|........||...|
  Rat   207 KKRSSGTTSG---GGGGEEPEQD------------------CAVTSGEELLALPPPPPPGGAVPS 250

  Fly   250 GSPS----HYLPPGHSPTPSSTPVSELSPEFP 277
            |.|:    ..||.|.|.:|..:.::.|.|:.|
  Rat   251 GVPAAAREGRLPSGLSASPQPSSIAPLRPQEP 282

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Dll	NP_001137759.1	Homeodomain	125..181	CDD:459649	25/55 (45%)
Pdx1	NP_074043.4	Transactivation domain	13..73		6/30 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	36..81		7/38 (18%)
		Antp-type hexapeptide	118..123		3/4 (75%)
		Homeodomain	147..203	CDD:459649	25/55 (45%)
		Nuclear localization signal. /evidence=ECO:0000250	197..203		3/5 (60%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	201..283		28/103 (27%)