Protein Alignment Dll and NKX2-8

DIOPT Version :10

• Sequence 1: NP_001137759.1
• Gene: Dll / 37973
• FlyBaseID: FBgn0000157
• Length: 347
• Species: Drosophila melanogaster
• Sequence 2: NP_055175.2
• Gene: NKX2-8 / 26257
• HGNCID: 16364
• Length: 239
• Species: Homo sapiens
• Alignment Length: 264
• Identity: 75/264 - (28%)
• Similarity: 105/264 - (39%)
• Gaps: 79/264 - (29%)

  Fly    69 RSALGYPFPPMHQNSYSGYHLGSYAP--------PCAS---------PPKDDFSISDKCEDSGLR 116
            ||.|..|       .....||....|        |||:         |..|:.|:.....||..|
Human    12 RSLLDLP-------EQDAQHLPRREPEPRAPQPDPCAAWLDSERGHYPSSDESSLETSPPDSSQR 69

  Fly   117 VNGK-------GKKMRKPRTIYSSLQLQQLNRRFQRTQYLALPERAELAASLGLTQTQVKIWFQN 174
            .:.:       .:|.:|.|.::|..|..:|.|||::.:||:.|||.:||:.|.||.|||||||||
Human    70 PSARPASPGSDAEKRKKRRVLFSKAQTLELERRFRQQRYLSAPEREQLASLLRLTPTQVKIWFQN 134

  Fly   175 RRSKYKKMMKAAQGPGTNSGMPLGGGGPNPGQHSPNQMHSGEL--ANG---RFLWAALETNGTLA 234
            .|.|    :|.|:.||              ...||:...|.||  |.|   |.:...|..:|
Human   135 HRYK----LKRARAPG--------------AAESPDLAASAELHAAPGLLRRVVVPVLVRDG--- 178

  Fly   235 LVHSTGGNNGGGSNSGSPSHYLPPGHSPTPSSTPVSELSPEFPPTG-------------LSPPTQ 286
              ...||  |||...|:.:.....| :|..::.|:    |.:|..|             |:.|..
Human   179 --QPCGG--GGGGEVGTAAAQEKCG-APPAAACPL----PGYPAFGPGSALGLFPAYQHLASPAL 234

  Fly   287 APWD 290
            ..|:
Human   235 VSWN 238

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Dll	NP_001137759.1	Homeodomain	125..181	CDD:459649	29/55 (53%)
NKX2-8	NP_055175.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..87		17/81 (21%)
		Homeodomain	85..141	CDD:459649	29/59 (49%)