Protein Alignment Dll and ALX3

DIOPT Version :10

• Sequence 1: NP_001137759.1
• Gene: Dll / 37973
• FlyBaseID: FBgn0000157
• Length: 347
• Species: Drosophila melanogaster
• Sequence 2: NP_006483.2
• Gene: ALX3 / 257
• HGNCID: 449
• Length: 343
• Species: Homo sapiens
• Alignment Length: 307
• Identity: 76/307 - (24%)
• Similarity: 115/307 - (37%)
• Gaps: 107/307 - (34%)

  Fly    56 GPQGGQDSGFPSPRSALGYPFPPMHQNSYSGYHLGSYAPPCASPPKDDFSISDKCEDSGLRVNGK 120
            ||:.|       |.:..|.|.|.:     :..||               .:|....||......|
Human   113 GPRDG-------PSNLQGSPGPCL-----ASLHL---------------PLSPGLPDSMELAKNK 150

  Fly   121 GKKMRKPRTIYSSLQLQQLNRRFQRTQYLALPERAELAASLGLTQTQVKIWFQNRRSKYKK---- 181
            .|| |:.||.:|:.||::|.:.||:|.|..:..|.:||....||:.:|::||||||:|::|
Human   151 SKK-RRNRTTFSTFQLEELEKVFQKTHYPDVYAREQLALRTDLTEARVQVWFQNRRAKWRKRERY 214

  Fly   182 -MMKAAQGPGTN----SGMPLGGGGPNPGQHSPNQMHSGELANGRFLWAALETNGTLALVHSTGG 241
             .::..:.|.|.    |.:|.....|             :|.|.  |||
Human   215 GKIQEGRNPFTAAYDISVLPRTDSHP-------------QLQNS--LWA---------------- 248

  Fly   242 NNGGGSNSGSPSHYLPPGHSPTPSSTPVSELSPEFPPTGLSPPTQAPWDQKPHWIDHKPPPQMTP 306
             :.|..:.|.|....|.| .|:|..:|.|.  |.....|..
Human   249 -SPGSGSPGGPCLVSPEG-IPSPCMSPYSH--PHGSVAGFM------------------------ 285

  Fly   307 QPPHPAATLHPQTHH-HNPPPQMGGYVPQYWYQPET-----NPSLVT 347
            ..|.|:|. ||..:. |..||.:||:.    ::|.:     :||||:
Human   286 GVPAPSAA-HPGIYSIHGFPPTLGGHS----FEPSSDGDYKSPSLVS 327

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Dll	NP_001137759.1	Homeodomain	125..181	CDD:459649	24/55 (44%)
ALX3	NP_006483.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..104
		PRK12323	<13..131	CDD:481241	7/29 (24%)
		Homeodomain	154..210	CDD:459649	24/55 (44%)