Protein Alignment Dll and Nkx2-1

DIOPT Version :10

• Sequence 1: NP_001137759.1
• Gene: Dll / 37973
• FlyBaseID: FBgn0000157
• Length: 347
• Species: Drosophila melanogaster
• Sequence 2: XP_006240178.1
• Gene: Nkx2-1 / 25628
• RGDID: 3866
• Length: 423
• Species: Rattus norvegicus
• Alignment Length: 330
• Identity: 94/330 - (28%)
• Similarity: 131/330 - (39%)
• Gaps: 79/330 - (23%)

  Fly    13 MDGGNTAASVT---PGINIPGKSAFVELQQHAAAGYGGIRSTYQHFG---PQ------GGQDSGF 65
            |:||...|.:.   .|...|..:|   :||||...:|.:.:.|....   ||      ||..:|.
  Rat    80 MEGGGLGAPLAAYRQGQAAPPAAA---MQQHAVGHHGAVTAAYHMTAAGVPQLSHSAVGGYCNGN 141

  Fly    66 PSPRSALGYPFPPMHQNSYSGYHLGSYAPPCASPPKDDFSISD-KCEDSGLRVNGKG-------- 121
            ....|.|. |:....:||.||  .|.|.   |:|.....:||. ....||:.::|.|
  Rat   142 LGNVSELP-PYQDTMRNSASG--PGWYG---ANPDPRFPAISRFMGPASGMNMSGMGGLGSLGDV 200

  Fly   122 -KKM--------RKPRTIYSSLQLQQLNRRFQRTQYLALPERAELAASLGLTQTQVKIWFQNRRS 177
             |.|        ||.|.::|..|:.:|.|||::.:||:.|||..||:.:.||.|||||||||.|.
  Rat   201 SKNMAPLPSAPRRKRRVLFSQAQVYELERRFKQQKYLSAPEREHLASMIHLTPTQVKIWFQNHRY 265

  Fly   178 KYKKMMK---AAQGPGTNSGMPLGGGGPNPGQHSPNQMHSGELANGRFLWAALETNG-------- 231
            |.|:..|   |.|....:||   ||||...|...|.|..:.:.:..|.....|..:|
  Rat   266 KMKRQAKDKAAQQQLQQDSG---GGGGGGGGAGCPQQQQAQQQSPRRVAVPVLVKDGKPCQAGAP 327

  Fly   232 ------------------TLALVHSTGGNNGGGSNSGSPSHYLPPGHSPTPSSTPVSELSPEFPP 278
                              ..|...:....:.|...:|..:|   |||.|..:..     ||:...
  Rat   328 APGAASLQGHAQQQAQQQAQAAQAAAAAISVGSGGAGLGAH---PGHQPGSAGQ-----SPDLAH 384

  Fly   279 TGLSP 283
            ...||
  Rat   385 HAASP 389

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Dll	NP_001137759.1	Homeodomain	125..181	CDD:459649	29/55 (53%)
Nkx2-1	XP_006240178.1	Homeodomain	213..269	CDD:459649	29/55 (53%)