DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Dll and Dlx5

DIOPT Version :9

Sequence 1:	NP_001137759.1	Gene:	Dll / 37973	FlyBaseID:	FBgn0000157	Length:	347	Species:	Drosophila melanogaster
Sequence 2:	NP_037075.1	Gene:	Dlx5 / 25431	RGDID:	2506	Length:	289	Species:	Rattus norvegicus

Alignment Length:	284	Identity:	107/284 - (37%)
Similarity:	127/284 - (44%)	Gaps:	79/284 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    54 HFGPQGGQDSGFPSPR--------------------SALGYPFPPMHQNSY-SGYHL--GSY--A 93
            ::.|.|....|:.||.                    ||.|||........| |.||.  |:|  .
  Rat    47 YYSPAGAAPHGYCSPTSASYRKALNPYQYQYHSVNGSAAGYPAKAYADYGYASPYHQYGGAYNRV 111

  Fly    94 PPCASPPKDDFSISDKCEDSGLRVNGKGKKMRKPRTIYSSLQLQQLNRRFQRTQYLALPERAELA 158
            |...|.|:.:.:     |.....||||.||:|||||||||.||..|.||||:|||||||||||||
  Rat   112 PSATSQPEKEVA-----EPEVRMVNGKPKKVRKPRTIYSSFQLAALQRRFQKTQYLALPERAELA 171

  Fly   159 ASLGLTQTQVKIWFQNRRSKYKKMMKAAQGPGTNSGMPLGGGGPNPGQHSPNQMHSGELA-NGRF 222
            ||||||||||||||||:|||.||:||               .|..|.:|||:.  |..:| |...
  Rat   172 ASLGLTQTQVKIWFQNKRSKIKKIMK---------------NGEMPPEHSPSS--SDPMACNSPQ 219

  Fly   223 LWAALETNGTLALVHSTGGNNGGGSNSGSPSHYLPPGHSPTPSSTPVS---ELSPEFPPTGLSPP 284
            ..|..|..|                :|.|.||: |..|..|.:.:|.|   |.|..:.|:..|..
  Rat   220 SPAVWEPQG----------------SSRSLSHH-PHAHPTTSNQSPASSYLENSASWYPSAASSI 267

  Fly   285 TQAPWDQKPHWIDHKPPPQMTPQP 308
            .           .|.|||.....|
  Rat   268 N-----------SHLPPPGSLQHP 280

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dll	NP_001137759.1	Homeobox	127..180	CDD:278475	46/52 (88%)
Dlx5	NP_037075.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..49		0/1 (0%)
		DLL_N	32..118	CDD:289198	18/70 (26%)
		Homeobox	140..193	CDD:278475	46/52 (88%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	198..253		20/73 (27%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	270..289		5/11 (45%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166346757
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0850
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	145	1.000	Inparanoid score	I4335
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1416398at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm63544
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24327
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X884
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	9	8.900