Protein Alignment Dll and Alx1

DIOPT Version :10

• Sequence 1: NP_001137759.1
• Gene: Dll / 37973
• FlyBaseID: FBgn0000157
• Length: 347
• Species: Drosophila melanogaster
• Sequence 2: NP_037053.1
• Gene: Alx1 / 25401
• RGDID: 2273
• Length: 326
• Species: Rattus norvegicus
• Alignment Length: 301
• Identity: 74/301 - (24%)
• Similarity: 112/301 - (37%)
• Gaps: 83/301 - (27%)

  Fly     1 MDAPDAPHTPKYMDGGNTAASVTPGI---NIPGKSAFVELQQHAAAGYGGIRSTYQHFGP----- 57
            :.:|.:.::..||..|.....|...:   :..||         |.||     ...|.|||
  Rat    10 LKSPPSKNSDFYMGTGGALEHVMETLDNESFYGK---------ATAG-----KCVQAFGPLPRAE 60

  Fly    58 -QGGQDSGFPSPRSALGYPF-----PPMH---QNSYSGYHLGSYAPPCASPPKDDF-SISDKCED 112
             ....|...|...|::.|..     .|:|   ..:..|.:....:|....|.|.:. .:.|||:.
  Rat    61 HHVRLDRTSPCQDSSVNYGITKVEGQPLHTELNRAMDGCNNLRMSPVKGMPEKSELDELGDKCDS 125

  Fly   113 SGLRVNGKGKKMRKPRTIYSSLQLQQLNRRFQRTQYLALPERAELAASLGLTQTQVKIWFQNRRS 177
                 |....|.|:.||.::||||::|.:.||:|.|..:..|.:||....||:.:|::||||||:
  Rat   126 -----NVSSSKKRRHRTTFTSLQLEELEKVFQKTHYPDVYVREQLALRTELTEARVQVWFQNRRA 185

  Fly   178 KYKKMMKAAQGPGTNSG---------MPLGGGGPNPGQHSPNQMHSGELANGRFLWAALETNGTL 233
            |::|..:..|.....|.         :|.....|             ::.|.  |||
  Rat   186 KWRKRERYGQIQQAKSHFAATYDISVLPRTDSYP-------------QIQNN--LWA-------- 227

  Fly   234 ALVHSTGGNNGGGS-------NSGSPSHYLPPGHSPTPSST 267
                   ||..|||       ...:.|...|..|||...|:
  Rat   228 -------GNTSGGSVVTSCMLPRDASSCMTPYSHSPRTDSS 261

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Dll	NP_001137759.1	Homeodomain	125..181	CDD:459649	25/55 (45%)
Alx1	NP_037053.1	Homeodomain	133..189	CDD:459649	25/55 (45%)
		Transactivation domain. /evidence=ECO:0000269|PubMed:12390248	192..326		19/100 (19%)
		OAR	302..320	CDD:461067
		OAR. /evidence=ECO:0000255|PROSITE-ProRule:PRU00138	306..319