Protein Alignment Dll and Nkx2-4

DIOPT Version :10

• Sequence 1: NP_001137759.1
• Gene: Dll / 37973
• FlyBaseID: FBgn0000157
• Length: 347
• Species: Drosophila melanogaster
• Sequence 2: NP_075993.1
• Gene: Nkx2-4 / 228731
• MGIID: 97349
• Length: 354
• Species: Mus musculus
• Alignment Length: 322
• Identity: 86/322 - (26%)
• Similarity: 108/322 - (33%)
• Gaps: 132/322 - (40%)

  Fly    10 PKYMDGGNTAASVTPGINIPGKSAFVELQQHAAAGYGGIRSTYQHFGPQGGQDSGFPSPRSALGY 74
            |..|.|.|.||:..                 |||......:|| |..|...|     .|.||:|
Mouse    68 PHAMAGHNAAAAAA-----------------AAAAAAAAAATY-HMPPGVSQ-----FPHSAMG- 108

  Fly    75 PFPPMHQNSYSGYHLGSYAPPCA--------------------SPPKDDFSISDKCEDS-GLRVN 118
                    ||....||:.....|                    :.|:.. |||.....| |:.|.
Mouse   109 --------SYCNGGLGNMGELPAYTDGMRGGAAAAATGWYGANTDPRYS-SISRFMGPSAGVNVA 164

  Fly   119 GKGK------------------KMRKPRTIYSSLQLQQLNRRFQRTQYLALPERAELAASLGLTQ 165
            |.|.                  ..||.|.::|..|:.:|.|||::.:||:.|||..||:.:.||.
Mouse   165 GMGSLTGIADAAKSLAPLHAAAPRRKRRVLFSQAQVYELERRFKQQKYLSAPEREHLASMIHLTP 229

  Fly   166 TQVKIWFQNRRSKYKKMM--KAAQ--------GPG----------------TNSGMPL--GGGGP 202
            |||||||||.|.|.|:..  ||||        ||.                ...|.|.  |.|.|
Mouse   230 TQVKIWFQNHRYKMKRQAKDKAAQQLQQEGGLGPPPPPPPPSPRRVAVPVLVKDGKPCQNGAGTP 294

  Fly   203 NPGQ------------------HSPNQMHSGELANGRFLWAALETNGTLALVHSTGGNNGGG 246
            .|||                  .||..:|.              ..|.||.:.:..|:.|||
Mouse   295 TPGQGGQQPQAPTPAPELEELSPSPPALHG--------------PGGGLAALDAATGDYGGG 342

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Dll	NP_001137759.1	Homeodomain	125..181	CDD:459649	29/55 (53%)
Nkx2-4	NP_075993.1	Homeodomain	189..245	CDD:459649	29/55 (53%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	245..329		18/97 (19%)