Protein Alignment Dll and Nkx2-1

DIOPT Version :10

• Sequence 1: NP_001137759.1
• Gene: Dll / 37973
• FlyBaseID: FBgn0000157
• Length: 347
• Species: Drosophila melanogaster
• Sequence 2: NP_001390509.1
• Gene: Nkx2-1 / 21869
• MGIID: 108067
• Length: 423
• Species: Mus musculus
• Alignment Length: 330
• Identity: 94/330 - (28%)
• Similarity: 133/330 - (40%)
• Gaps: 79/330 - (23%)

  Fly    13 MDGGNTAASVT---PGINIPGKSAFVELQQHAAAGYGGIRSTYQHFG---PQ------GGQDSGF 65
            |:||...|.:.   .|...|..:|   :||||...:|.:.:.|....   ||      ||..:|.
Mouse    80 MEGGGLGAPLAAYRQGQAAPPAAA---MQQHAVGHHGAVTAAYHMTAAGVPQLSHSAVGGYCNGN 141

  Fly    66 PSPRSALGYPFPPMHQNSYSGYHLGSYAPPCASPPKDDFSISD-KCEDSGLRVNGKG-------- 121
            ....|.|. |:....:||.||  .|.|.   |:|.....:||. ....||:.::|.|
Mouse   142 LGNMSELP-PYQDTMRNSASG--PGWYG---ANPDPRFPAISRFMGPASGMNMSGMGGLGSLGDV 200

  Fly   122 -KKM--------RKPRTIYSSLQLQQLNRRFQRTQYLALPERAELAASLGLTQTQVKIWFQNRRS 177
             |.|        ||.|.::|..|:.:|.|||::.:||:.|||..||:.:.||.|||||||||.|.
Mouse   201 SKNMAPLPSAPRRKRRVLFSQAQVYELERRFKQQKYLSAPEREHLASMIHLTPTQVKIWFQNHRY 265

  Fly   178 KYKKMMK---AAQGPGTNSGMPLGGGGPNPGQHSPNQMHSGE-----------LANGRFLWAALE 228
            |.|:..|   |.|....:||   ||||...|...|.|..:.:           :.:|:...|...
Mouse   266 KMKRQAKDKAAQQQLQQDSG---GGGGGGGGAGCPQQQQAQQQSPRRVAVPVLVKDGKPCQAGAP 327

  Fly   229 TNGTLALVH---------------STGGNNGGGSNSGSPSHYLPPGHSPTPSSTPVSELSPEFPP 278
            ..|..:|..               :....:.|...:|..:|   |||.|..:..     ||:...
Mouse   328 APGAASLQSHAQQQAQQQAQAAQAAAAAISVGSGGAGLGAH---PGHQPGSAGQ-----SPDLAH 384

  Fly   279 TGLSP 283
            ...||
Mouse   385 HAASP 389

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Dll	NP_001137759.1	Homeodomain	125..181	CDD:459649	29/55 (53%)
Nkx2-1	NP_001390509.1	Homeodomain	213..269	CDD:459649	29/55 (53%)