Protein Alignment Dll and EVX1

DIOPT Version :10

• Sequence 1: NP_001137759.1
• Gene: Dll / 37973
• FlyBaseID: FBgn0000157
• Length: 347
• Species: Drosophila melanogaster
• Sequence 2: NP_001980.1
• Gene: EVX1 / 2128
• HGNCID: 3506
• Length: 407
• Species: Homo sapiens
• Alignment Length: 347
• Identity: 87/347 - (25%)
• Similarity: 124/347 - (35%)
• Gaps: 100/347 - (28%)

  Fly     4 PDAPHTPKYMDGGNTAASVTPGINIPGKSAF-----VELQQHAAAGYGGIRSTYQHFGPQGGQDS 63
            |.||........|..::|.|       :|.|     |......|.|    .:.||| ....|.::
Human    96 PPAPSVDSLSGQGQPSSSDT-------ESDFYEEIEVSCTPDCATG----NAEYQH-SKGSGSEA 148

  Fly    64 GFPSPRSALGYPFPPMHQNSYSGYHLGSYAPPCASPPKDDFSISDKCEDSGLRVNGKGKKMRKPR 128
            ...||..  |...|..:..|..|...|:.|  |        |.||              :||:.|
Human   149 LVGSPNG--GSETPKSNGGSGGGGSQGTLA--C--------SASD--------------QMRRYR 187

  Fly   129 TIYSSLQLQQLNRRFQRTQYLALPERAELAASLGLTQTQVKIWFQNRRSKYKKMMKAAQGPG--- 190
            |.::..|:.:|.:.|.|..|::.|.|.||||:|.|.:|.:|:||||||.|.|:...|...|.
Human   188 TAFTREQIARLEKEFYRENYVSRPRRCELAAALNLPETTIKVWFQNRRMKDKRQRLAMTWPHPAD 252

  Fly   191 ------TNSGMPLGGGGPNP-------GQHSPNQMHSGELANGRFLWAALETNGTL--------- 233
                  ..|.....||.|.|       ..:||..:.:...|:.    ||...:|:|
Human   253 PAFYTYMMSHAAAAGGLPYPFPSHLPLPYYSPVGLGAASAASA----AASPFSGSLRPLDTFRVL 313

  Fly   234 -----------ALVHS---TGGNNGGGSNSGSPSHYLPPGHSP--------------TPSSTPVS 270
                       |..|.   .|..:|.|:::|.|...|.....|              |.:||..|
Human   314 SQPYPRPELLCAFRHPPLYPGPAHGLGASAGGPCSCLACHSGPANGLAPRAAAASDFTCASTSRS 378

  Fly   271 ELSPEFPPTGLSPPTQAPWDQK 292
            :....|.|:.||..:....||:
Human   379 DSFLTFAPSVLSKASSVALDQR 400

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Dll	NP_001137759.1	Homeodomain	125..181	CDD:459649	25/55 (45%)
EVX1	NP_001980.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	29..120		7/30 (23%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	137..179		13/54 (24%)
		Homeodomain	184..240	CDD:459649	25/55 (45%)