Protein Alignment Dll and Pdx1

DIOPT Version :10

• Sequence 1: NP_001137759.1
• Gene: Dll / 37973
• FlyBaseID: FBgn0000157
• Length: 347
• Species: Drosophila melanogaster
• Sequence 2: NP_032840.1
• Gene: Pdx1 / 18609
• MGIID: 102851
• Length: 284
• Species: Mus musculus
• Alignment Length: 254
• Identity: 74/254 - (29%)
• Similarity: 101/254 - (39%)
• Gaps: 60/254 - (23%)

  Fly    59 GGQDSGFPSPRSALGYPFPPMHQNSYSGYHLGSYAPP---CASPPKDDFSISDKCEDSGL----R 116
            |..:.|  ||.....|..||:..:..:|.||..:.|.   .|.||...|  .:..|..||    |
Mouse    55 GSLEQG--SPPDISPYEVPPLASDDPAGAHLHHHLPAQLGLAHPPPGPF--PNGTEPGGLEEPNR 115

  Fly   117 VN-------------GKG-----------KKMRKPRTIYSSLQLQQLNRRFQRTQYLALPERAEL 157
            |.             .||           ::.::.||.|:..||.:|.:.|...:|::.|.|.||
Mouse   116 VQLPFPWMKSTKAHAWKGQWAGGAYTAEPEENKRTRTAYTRAQLLELEKEFLFNKYISRPRRVEL 180

  Fly   158 AASLGLTQTQVKIWFQNRRSKYKKMMKAAQGPGTNSGMPLGGGGPNPGQHSPNQMHSGELANGRF 222
            |..|.||:..:||||||||.|:||.....:..||.||   ||||..|.|.
Mouse   181 AVMLNLTERHIKIWFQNRRMKWKKEEDKKRSSGTPSG---GGGGEEPEQD--------------- 227

  Fly   223 LWAALETNGTLALVHSTGGNNGGGSNSGSPS----HYLPPGHSPTPSSTPVSELSPEFP 277
               ...|:|...|........||....|.|:    ..||.|.|.:|..:.::.|.|:.|
Mouse   228 ---CAVTSGEELLAVPPLPPPGGAVPPGVPAAVREGLLPSGLSVSPQPSSIAPLRPQEP 283

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Dll	NP_001137759.1	Homeodomain	125..181	CDD:459649	25/55 (45%)
Pdx1	NP_032840.1	Transactivation domain. /evidence=ECO:0000250	13..73		6/19 (32%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	30..116		18/64 (28%)
		Antp-type hexapeptide	119..124		0/4 (0%)
		Homeodomain	148..204	CDD:459649	25/55 (45%)
		Nuclear localization signal	198..204		3/5 (60%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	202..284		27/103 (26%)